Investigation of mechanisms of human mast cell activation by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and involvement of asthma inception by these viruses

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Although asthma inception is associated with infection with respiratory syncytial virus (RSV) and/or human rhinovirus (HRV), the mechanisms remains unclear. Since we found elevated concentration of mast cell tryptase in nasal discharges/sputa from children under 3 years, who had RSV-induced bronchiolitis with wheezing in the first time in their lives, we hypothesized that these viruses might directly activate human mast cells to induce degranulation. In our in vitro studies, these viruses did not directly activate human mast cells to induce degranulation. Concentrations of RANTES and TGF-beta in nasal secretions/sputa, which were taken at the first time wheezing in their lives from children with no family history of asthma were significantly higher in children who have had wheezing repeatedly than those who have had no repeated wheezing.