Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy
Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy
批准号:
20591248
负责人:
SAIKAWA Yutaka
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We constructed the 3-dimmensional computer simulation system for investigation of cellular dynamics in normal granulopoiesis. Granulocytic cell dynamics under the simulation of chemotherapy and G-CSF rescue fitted well to the cell behavior under clinical situations. A model of acute myelogenous leukemia was simulated by means of introducing leukemic stem cell systems.
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Dense methylation patterns of CD10-negative infant acute lymphoblastic leukemia with MLL gene arrangements
CD10阴性婴儿急性淋巴细胞白血病MLL基因排列的密集甲基化模式
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[本名浩子, 合井久美子, T. Horisawa, 内野茂夫, Saikawa Y]
通讯作者:
Saikawa Y
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene
MLL/AF4融合基因婴儿急性淋巴细胞白血病CD10基因启动子1型和2型调控区的密集甲基化
DOI:
--
发表时间:
2010
期刊:
J Pediatr Hematol Oncol 32
影响因子:
--
作者:
[Ikawa Y., Saikawa Y.]
通讯作者:
Saikawa Y.
骨髄系造血のコンピューターシミュレーション
骨髓造血的计算机模拟
DOI:
--
发表时间:
2010
期刊:
金沢大学十全医学会雑誌 第119巻
影响因子:
--
作者:
[佐柳友規, 他, 灘波隆志, 犀川太]
通讯作者:
犀川太
Conputational Hematology in systems biology
系统生物学中的计算血液学
DOI:
--
发表时间:
2008
期刊:
Cellular automata LNCS5191
影响因子:
--
作者:
[Horisawa T., Komatsuzaki T., Saikawa Y.]
通讯作者:
Saikawa Y.
共 8 条
Computing analysis of leukemic stem cell dynamics in acute myelocytic leukemia
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批准号:19K08356
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2019
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负责人:SAIKAWA Yutaka
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依托单位:
Kinetic analysis of minimal residual disease using 3-dimentinal computational models of human granulopoiesis and development of risk of relapse-stratified treatment of pediatric leukemia.
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批准号:17591073
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:SAIKAWA Yutaka
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依托单位:
Analysis of Alu-mediated genomic deletion in a case with hemeooxygenase-1 deficiency
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批准号:13670788
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2001
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负责人:SAIKAWA Yutaka
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依托单位:
Identification and cDNA cloning of the transcriptional factors regulating the tissue-specific expression of human alpha-folate receptor gene
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批准号:09670793
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1997
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负责人:SAIKAWA Yutaka
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依托单位:
海外基金