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Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy

Computational leukemic stem cell models in systems biology for predicting relapse and development of risk-stratified chemotherapy
系统生物学中用于预测复发和风险分层化疗发展的计算白血病干细胞模型
批准号:
20591248
负责人:
SAIKAWA Yutaka
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We constructed the 3-dimmensional computer simulation system for investigation of cellular dynamics in normal granulopoiesis. Granulocytic cell dynamics under the simulation of chemotherapy and G-CSF rescue fitted well to the cell behavior under clinical situations. A model of acute myelogenous leukemia was simulated by means of introducing leukemic stem cell systems.
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会议论文
Dense methylation patterns of CD10-negative infant acute lymphoblastic leukemia with MLL gene arrangements
CD10阴性婴儿急性淋巴细胞白血病MLL基因排列的密集甲基化模式
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [本名浩子, 合井久美子, T. Horisawa, 内野茂夫, Saikawa Y]
通讯作者: Saikawa Y
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene
MLL/AF4融合基因婴儿急性淋巴细胞白血病CD10基因启动子1型和2型调控区的密集甲基化
DOI: --
发表时间: 2010
期刊: J Pediatr Hematol Oncol 32
影响因子: --
作者: [Ikawa Y., Saikawa Y.]
通讯作者: Saikawa Y.
DOI: --
发表时间: 2010
期刊: 金沢大学十全医学会雑誌 第119巻
影响因子: --
作者: [佐柳友規, 他, 灘波隆志, 犀川太]
通讯作者: 犀川太
8
    Computing analysis of leukemic stem cell dynamics in acute myelocytic leukemia
    • 批准号:
      19K08356
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2019
    • 负责人:
      SAIKAWA Yutaka
    • 依托单位:
    Kinetic analysis of minimal residual disease using 3-dimentinal computational models of human granulopoiesis and development of risk of relapse-stratified treatment of pediatric leukemia.
    • 批准号:
      17591073
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      SAIKAWA Yutaka
    • 依托单位:
    Analysis of Alu-mediated genomic deletion in a case with hemeooxygenase-1 deficiency
    • 批准号:
      13670788
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      2001
    • 负责人:
      SAIKAWA Yutaka
    • 依托单位:
    Identification and cDNA cloning of the transcriptional factors regulating the tissue-specific expression of human alpha-folate receptor gene
    • 批准号:
      09670793
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      1997
    • 负责人:
      SAIKAWA Yutaka
    • 依托单位:
    海外基金