The role of Hic-5 in intractable glomerulonephritis in children

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The purpose of this research is to clarify the expression of Hic-5 in nephritic glomeruli and how Hic-5 affects mesangial cell (MC) function. Immunohistochemistry showed that the expression of Hic-5 was increased in MC in human and rat mesangial proliferative glomerulonephritis (GN). Hic-5 expression was significantly correlated with extracellular matrix (ECM) accumulation and glomerular cell number in patients and GN rats. TGF- up-regulated Hic-5 protein levels by human cultured MCs. Knockdown of Hic-5 by siRNA reduced ECM remodeling in collagen gels. Thus, our findings suggest that Hic-5 is involved in the development of glomerulonephritis. Controlling Hic-5 activity might be a therapy strategy for GN.