New evaluation for severity of Kawasaki disease using HMGB1 values.

我们研究了高迁移率族蛋白1（HMGB1）值评估KD严重程度的有效性。研究方法：对初始静脉注射免疫球蛋白（IVIG）的应答者（143例患者）和无应答者（23例患者）的血清HMGB1值进行比较。结果：与应答者相比，无应答者HMGB1水平显著升高。ROC分析显示HMGB1对无应答者的最佳临界值。高HMGB1敏感性为43%，准确性为73%。当预测的无应答者定义为群马评分为5或以上或HMGB1值高的患者时，敏感性为74%，准确性为63%。结论：联合应用HMGB1值和Gunma评分可作为判断川崎病严重程度的指标，并可作为预测IVIG无效的指标。

We examined the efficacy of high mobility group box 1 (HMGB1) value for evaluating the severity of KD. Methods : Serum HMGB1 values were compared between the responders (143 patients) to initial intravenous immunoglobulin (IVIG) and nonresponders (23 patients). Results : Compared with responders, non-responders showed significantly elevated HMGB1 values. ROC analysis revealed an optimal cut-off value for HMGB1 for nonresponders. The sensitivity with high HMGB1 was 43% and accuracy 73%. When predicted non-responder is defined as a patient with Gunma score of 5 or over or high HMGB1 value, the sensitivity was 74% and accuracy 63%. Conclusion : Combinational use of HMGB1 value and Gunma score is useful for determine the severity of KD as the prediction for nonresponder of IVIG.