Cerebral oxygenation and hemodynamics in premature infant using near-infrared time-resolved spectroscopy

使用近红外时间分辨光谱研究早产儿的脑氧合和血流动力学

• 批准号: 20591299
• 负责人: ISOBE Kenichi
• 金额: $ 2.91万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591299/
• 关键词: 貧血; 脳内酸素化状態; 脳血液量; 近赤外線分光法; 時間分解分光装置; 新生児未熟児; 新生仔豚; 新生児; 未熟児; 脳循環

Anemia of prematurity is a common disease, particularly in very low birth weight infants, and transfusion is an important treatment. However, there is no clear evidence for the currently widely used transfusion criteria using the blood hemoglobin level (Hb) and hematocrit value (Ht). Thus, preparation of new transfusion criteria using an index other than the Hb and Ht has been attempted. We measured the cerebral Hb concentration, Hb oxygen saturation (ScO_2) and cerebral blood volume (CBV) in anemic animal model and infants with anemia of prematurity using time-resolved near-infrared spectroscopy (TRS). In animal study, we demonstrated that TRS method could be used to monitor the cerebral oxygenation and hemodynamics in the anemic neonates at the bedside. Thus, fifteen measurements were performed in 10 premature infants. CBV significantly decreased and ScO_2 significantly increased after transfusion. Measurement of CBV and ScO_2 is useful to investigate the necessity of transfusion.

早产儿贫血是一种常见病，特别是在出生体重极低的婴儿中，输血是一种重要的治疗方法。然而，目前广泛使用的以血红蛋白水平（Hb）和红细胞压积值（Ht）作为输血标准尚无明确的证据。因此，已经尝试使用Hb和Ht以外的指标制定新的输血标准。采用时间分辨近红外光谱（TRS）技术测定了贫血动物模型和早产儿的脑Hb浓度、血氧饱和度（ScO_2）和脑血容量（CBV）。在动物实验中，我们证明了TRS方法可以在床边监测贫血新生儿的脑氧合和血流动力学。因此，对10名早产儿进行了15次测量。输血后CBV显著降低，ScO_2显著升高。CBV和ScO_2的测定有助于探讨输血的必要性。

项目成果

未熟児貧血における輸血療法時の脳血液量、脳内ヘモグロビン酸素飽和度の変化について

早产儿贫血输血治疗中脑血容量及脑血红蛋白氧饱和度的变化

• 发表时间: 2011
• 作者: 高木 豪;西崎 有利子;松井 ふみ子;東 雄二郎;東雄二郎,高木豪,西崎有利子,松井ふみ子,中西圭子,時田義人;小谷野 耕佑
• 通讯作者: 小谷野 耕佑

Effects of hemodilution on cerebral optical properties and hemodynamics in newborn piglets using near-infrared time-resolved spectroscopy

使用近红外时间分辨光谱研究血液稀释对新生仔猪脑光学特性和血流动力学的影响

• 发表时间: 2008
• 作者: Kenichi Isobe;et al.
• 通讯作者: et al.

The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic premature infants

输血对贫血早产儿脑血流动力学和氧合的影响

• 发表时间: 2011
• 作者: Kosuke Koyano;Kenichi Isobe et al.
• 通讯作者: Kenichi Isobe et al.

Changes in cerebral blood volume of piglets with acute anemia induced by partial blood exchange transfusion

部分换血致急性贫血仔猪脑血容量的变化

• 发表时间: 2010
• 作者: Kosuke Koyano;Kenichi Isobe et al.
• 通讯作者: Kenichi Isobe et al.

Hemodynamic changes in the breast and frontal cortex of mother during breastfeeding

母乳喂养期间母亲乳房和额叶皮质的血流动力学变化

• 发表时间: 2011
• 期刊: Pediatr Res
• 影响因子: 3.6
• 作者: Tanimoto K;Kusaka T;Nishida T;Ogawa K;Kato I;Ijichi S;Mikami J;Sobue I;Isobe K;Itoh S
• 通讯作者: Itoh S