Cerebral oxygenation and hemodynamics in premature infant using near-infrared time-resolved spectroscopy

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Anemia of prematurity is a common disease, particularly in very low birth weight infants, and transfusion is an important treatment. However, there is no clear evidence for the currently widely used transfusion criteria using the blood hemoglobin level (Hb) and hematocrit value (Ht). Thus, preparation of new transfusion criteria using an index other than the Hb and Ht has been attempted. We measured the cerebral Hb concentration, Hb oxygen saturation (ScO_2) and cerebral blood volume (CBV) in anemic animal model and infants with anemia of prematurity using time-resolved near-infrared spectroscopy (TRS). In animal study, we demonstrated that TRS method could be used to monitor the cerebral oxygenation and hemodynamics in the anemic neonates at the bedside. Thus, fifteen measurements were performed in 10 premature infants. CBV significantly decreased and ScO_2 significantly increased after transfusion. Measurement of CBV and ScO_2 is useful to investigate the necessity of transfusion.