Investigation on cell specific mechanism in the tube-like differentiation in extra-villous trophoblast

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We investigated on cell specific mechanism in the tube-like differentiation in extra-villous trophoblast. As a result, the gene expression profile in EVT during tube formation is very different from that of endothelial cells despite these cells presented morphological change. HIF1A has a crucial role in regulating EVT behavior including matrigel-induced endovascular differentiation under normoxic condition. On the contrary, ROS produced by XO in hypoxia-reperfusion induced apoptosis and affected invasion ability and differentiation in EVT. M directly injures the placental syncytiotrophoblast in PIH patients and that elevated UA in PIH patients, at least partly, indicates placental damage induced by ROS. Moreover, the role and significance of ROS injury in the placenta may differ between early-onset and late-onset type PIH.