Analyses on Perinatal Brain Injury on the basis of Evaluation of Fetus-Placenta System.

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There were no significant differences in the cord blood levels of Tau protein, S-100B, 8OHdG, or MMP-9 between the preterm infants with and without periventricular leukomalacia. We examined the difference in mRNA expression in umbilical cord blood according to the presence or absence of periventricular leukomalacia. Five of the 15 up-regulated genes are coding ribosomal proteins, and another encodes a translation elongation factor. This may indicate an activation of lymphocytes during the fetal period. We examined the difference in mRNA expression in the cerebrum between fetal growth retardation model rats and control ones. Seventy-three genes were up-regulated in fetal growth retardation model rats, and 55 were down-regulated. We evaluated the effect of maternal docosahexaenoic acid-enriched diet on the brain of fetal growth retardation model rats. The percentage of docosahexaenoic acid was higher in the docosahexaenoic acid-enriched group than in the control group.