Analyses on Perinatal Brain Injury on the basis of Evaluation of Fetus-Placenta System.

早产儿脑室周围白质软化组与非脑室周围白质软化组脐血Tau蛋白、S-100B、8OHdG、MMP9水平差异无统计学意义。根据脑室周围白质软化的存在与否，我们检测了脐带血中mRNA表达的差异。在15个上调的基因中，有5个编码核糖体蛋白，另一个编码翻译延长因子。这可能表明淋巴细胞在胎儿期处于激活状态。我们检测了胎儿生长迟缓模型大鼠和对照组大鼠大脑中mRNA表达的差异。胎儿生长迟缓模型大鼠有73个基因表达上调，55个基因表达下调。我们评价了母体富含二十二碳六烯酸的饮食对胎儿生长迟缓模型大鼠大脑的影响。二十二碳六烯酸富集组的二十二碳六烯酸百分比高于对照组。

There were no significant differences in the cord blood levels of Tau protein, S-100B, 8OHdG, or MMP-9 between the preterm infants with and without periventricular leukomalacia. We examined the difference in mRNA expression in umbilical cord blood according to the presence or absence of periventricular leukomalacia. Five of the 15 up-regulated genes are coding ribosomal proteins, and another encodes a translation elongation factor. This may indicate an activation of lymphocytes during the fetal period. We examined the difference in mRNA expression in the cerebrum between fetal growth retardation model rats and control ones. Seventy-three genes were up-regulated in fetal growth retardation model rats, and 55 were down-regulated. We evaluated the effect of maternal docosahexaenoic acid-enriched diet on the brain of fetal growth retardation model rats. The percentage of docosahexaenoic acid was higher in the docosahexaenoic acid-enriched group than in the control group.