Research of the role of tenascin C in coronary development

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Cells destined to form the coronary vasculature which supply oxygen and nutrients to the heart are thought to originate in the proepicardium. We examined an extracellular glycoprotein tenascin C in formation of the coronary stem and epithelial mesenchymal transformation of proepicardium-derived cells. Expression of tenascin C was seen in developing coronary stems and coronary smooth muscle cells. It is suggested that tenascin C facilitates the differentiation of proepicardium-derived cells into myofibroblast/smooth muscle cells, however, not induce the invasion/migration of the cells in vitro system.