权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Functional analysis of meltrin β/ADAM 19 in formation of the cardiac coronary artery

Meltrin β/ADAM 19 在心脏冠状动脉形成中的功能分析

基本信息

批准号：
17591117
负责人：
TOMITA Sachiko
金额：
$ 2.3万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591117/
关键词：
heart metalloprotease coronary artery development morphogenesis 派生

项目摘要

ADAMs (a disintegrin and metalloprotease) family are known to be membrane-anchored glycoproteins that contain metalloprotease and disintegrin domains, and participate in the ectodomain shedding of various membrane-anchored proteins, growth factors, intercellular signaling molecules, and adhesion molecules. ADAMs play important roles in a variety of biological processes, including neurogenesis, fertilization, angiogenesis, cardiogenesis and cancer. Meltrin β/ADAM19 which is a member of the ADAMs deficient mice showed ventricular septal defect and immature valve formation. Meltrin β expressed in cardiac neural crest cells is required for ventricular septum and valve formations. Meltrin β-deficient neural crest cells migrated into the heart normally, however, they could not properly fuse the both ridges of the cushion tissues in the proximal outflow tract. Then this let to defect the membranous of the ventricular septum. Meltrin β-deficient mice showed anomalies of the coronary arteries which are aneurysm, surpentine, and orifice, formed coronary arteriovenous fistula that is influent into the ventricular septum and connected to the ventricle directly. In the ventricular septum the septum branch of the coronary artery seems like to form a big mass as a new another ventricle. We could find the blood flow of the septum coronary artery showed the regurgitant flow during systolic.

亚当斯（去整合素和金属蛋白酶）家族是膜锚定糖蛋白，其含有金属蛋白酶和去整合素结构域，并且参与各种膜锚定蛋白、生长因子、细胞间信号传导分子和粘附分子的胞外域脱落。亚当斯在多种生物学过程中发挥重要作用，包括神经发生、受精、血管生成、心脏发生和癌症。Meltrin β/ADAM 19是亚当斯缺陷小鼠中的一员，表现为室间隔缺损和未成熟瓣膜形成。在心脏神经嵴细胞中表达的Meltrin β是室间隔和瓣膜形成所必需的。Meltrin β缺陷的神经嵴细胞可以正常迁移入心脏，但不能与近端流出道垫组织的两个嵴完全融合。这样就可以使室间隔膜缺损. Meltrin β基因缺陷小鼠冠状动脉出现异常，表现为动脉瘤、冠状动脉壁、冠状动脉开口，形成冠状动脉动静脉瘘，流入室间隔，直接与心室相连。冠状动脉的间隔分支在室间隔内形成一个巨大的团块，形成一个新的心室。收缩期可见冠状动脉间隔血流呈逆向流动。