Novel therapeutic approach to skin diseases with protein-transduction technology
Novel therapeutic approach to skin diseases with protein-transduction technology
批准号:
20591316
负责人:
SHIBAGAKI Naotaka
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Protein-transduction domains (PTDs) are short stretches of cationic amino acids that enable peptides, proteins, oligonucleotides, and other reagents to efficiently enter multiple cell types. Therefore, PTDs offer unique therapeutic opportunities for the treatment of many diseases, including skin cancer. Novel STAT3 inhibitor ; R9-GRIM19 significantly reduced STAT3-dependent transcription in vitro, and tumor growth in vivo.
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Intradermal injiections of polyarginin-containing immunogenic antigens preferentially elicit Tc1 and Th1 activation and antitumor immunity
皮内注射含聚精氨酸的免疫原性抗原优先引发 Tc1 和 Th1 激活和抗肿瘤免疫
DOI:
--
发表时间:
2010
期刊:
British Journal of Dermatology 162
影响因子:
--
作者:
[H.Mitsui, T.Okamoto, M.Kanzaki, T.Inozume, N Shibagaki, S Shimada]
通讯作者:
S Shimada
腫瘍免疫療法の新たな展望(教育講演)
肿瘤免疫治疗新前景(教育讲座)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tanimura S, Tadokoro Y, Inomata K, Tanaka Y, Nishie W, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK, 柴垣直孝]
通讯作者:
柴垣直孝
癌免疫療法のトピックスと展望
癌症免疫治疗的主题和前景
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大川哲平, 遠藤明史, 満生紀子, 青木由貴, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀, 柴垣直孝]
通讯作者:
柴垣直孝
Novel Immunotherapeutic approaches to skin cancer treatments using protein transduction technology
使用蛋白质转导技术治疗皮肤癌的新型免疫治疗方法
DOI:
10.1016/j.jdermsci.2010.12.003
发表时间:
2011
期刊:
Journal of Dermatological Science
影响因子:
4.6
作者:
[柴垣直孝, 島田眞路, NAOTAKA SHIBAGAKI]
通讯作者:
NAOTAKA SHIBAGAKI
腫瘍免疫療法の新たな展望
肿瘤免疫治疗新前景
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shirafuji Y, Maeda Y, Iwatsuki K., 足立雄一, Akiyama M, Hirabayashi S et al., 柴垣直孝]
通讯作者:
柴垣直孝
共 20 条
Analyses for the establishment of the effective immunotherapy to melanoma-bearing hosts
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批准号:23591613
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2011
-
负责人:SHIBAGAKI Naotaka
-
依托单位:
Analyses for the enhancing methods of tumor vaccination therapy in cancer-bearing hosts
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批准号:18591241
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
-
财政年份:2006
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负责人:SHIBAGAKI Naotaka
-
依托单位:
Analysis of Antitumor Immunity Using Dendritic Cells Treated with Various Protein-transduction Domain (PTD)-containing Protein Antigen
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批准号:15390339
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2003
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负责人:SHIBAGAKI Naotaka
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依托单位:
Basic Analysis of Immuno-gene Therapy for Melanoma Using Functional Characteristic of CD82
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批准号:09670905
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1997
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负责人:SHIBAGAKI Naotaka
-
依托单位:
海外基金