Gene therapy for refractory skin ulcer by using Histone deacetylase inhibitor

组蛋白脱乙酰酶抑制剂治疗难治性皮肤溃疡的基因治疗

• 批准号: 20591333
• 负责人: YASUKAWA Kana
• 金额: $ 3.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591333/
• 关键词: 皮膚炎症; 再生医療; 免疫; 遺伝子治療; 再生治療

In this study, we demonstrated that HDAC inhibitors increased transient transgene expression. This effect was observed by not only local injection but also external use. However, an ulcer reduction effect was not observed in the study using the growth factor gene. For this result, it was thought that the examination of the gene introduction number of times and the combination of growth factors were necessary.

在这项研究中，我们证明了HDAC抑制剂增加了瞬时转基因表达。这种效果不仅可以通过局部注射观察到，也可以通过外用观察到。然而，在使用生长因子基因的研究中没有观察到减少溃疡的效果。对于这一结果，认为基因导入次数的检测和生长因子的组合是必要的。

项目成果

Unusual annular purpura and erythema in a patient with malignant lymphoma accompanied with hyperglovulinemia.

恶性淋巴瘤患者伴有高球蛋白血症，出现异常的环状紫癜和红斑。

• 发表时间: 2008
• 期刊: International Journal of Dermatology 47(3)
• 作者: Yasukawa K;Kato N;Hamasaka A;Hata H
• 通讯作者: Hata H

Human IgGl monoclonal antibody against human collagen 17 noncollagenous 16A domain induces blisters via complement activation in experimental bullous pemphigoid model.

针对人胶原17非胶原16A结构域的人IgG1单克隆抗体在实验性大疱性类天疱疮模型中通过补体激活诱导水疱。

• 发表时间: 2010
• 期刊: Journal of Immunology
• 影响因子: 4.4
• 作者: Li Q;Ujiie H;Shibaki A;et al.
• 通讯作者: et al.

Human IgG1 Monoclonal Antibody against Human Collagen 17 Noncollagenous 16A Domain Induces Blisters via Complement Activation in Experimental Bullous Pemphigoid Model

• DOI: 10.4049/jimmunol.1000667
• 发表时间: 2010-12-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Li, Qiang;Ujiie, Hideyuki;Shimizu, Hiroshi
• 通讯作者: Shimizu, Hiroshi

Blockade of autoantibody-initiated tissue damage by using recombinant fabantibody traoments against pathogenic autoantiqen.

通过使用针对致病性自身抗原的重组 fab 抗体治疗来阻断自身抗体引发的组织损伤。

• 发表时间: 2010
• 期刊: Human mutation
• 影响因子: 3.9
• 作者: Wang G;Shibaki A;et al.
• 通讯作者: et al.

Unusual annular purpura and erytehma in a patient with malignant ly mphoma accompanied with hyperglobulinemia

恶性淋巴瘤伴高球蛋白血症患者异常环状紫癜和红斑

• 发表时间: 2008
• 期刊: International journal of Dermatology 47
• 作者: Yasukawa K;Kato N;Hamasaka A;Hata H;Yasukawa K
• 通讯作者: Yasukawa K