The role of the bias in Th-subset 1/2/17 on pathogenesis of atopic dermatitis.

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Recent studies demonstrated that both impaired skin barrier function and allergic immunonogical property are important aspects of the pathogenesis of atopic dermatitis and contact dermatitis. However, the role of Th17 cells in the pathogenesis of contact dermatitis is not clear. In this study, we investigated the role of Th17 cells in allergic contact dermatitis. The hematopoietic stem cells which constitutively overexpress ROR・t were transplanted to irradiated mice and artificial allergic dermatitis was induced to the mice. The dermatitis in the transplanted mice was suppressed compared to the control mice. These findings indicate that constitutive overexpression of ROR ・t results in the increase of Th17 cells, but suppressed allergy due to the increase of Treg cells.