Neural mechanisms underlying stress vulnerability - involvement of neurogenesis in mood disorder

在这项研究中，我们特别注意到成人海马体中的神经发生是大脑应激易感性的分子基础。利用成年大鼠齿状回衍生前体细胞（ADP）进行体外研究，观察抗抑郁药、情绪稳定剂和单胺类药物对ADP的直接影响。其中，情绪稳定剂、去甲肾上腺素、多巴胺在细胞增殖、凋亡、分化等方面均有一定作用。此外，我们发现CaMKIV通过神经发生参与抗抑郁药的作用。所有这些发现将有助于研制新型抗抑郁药。

In this study we took particular note of neurogenesis in the adult hippocampus as molecular basis of stress vulnerability in the brain. In vitro studies using adult rat dentate gyrus-derived precursor cells (ADP) were done to see the direct effects of antidepressants, mood stabilizers and monoamines on them. Among them, mood stabilizers, noradrenaline, and dopamine had some effects in the aspect the proliferation, apoptosis, and differentiation. In addition we found out the involvement of CaMKIV in the action of antidepressants through neurogenesis. All these findings will contribute to make novel antidepressants.