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The role of adult hippocampal neurogenesis underlying stress vulnerability

成人海马神经发生在应激脆弱性中的作用

基本信息

批准号：
18591269
负责人：
NAKAGAWA Shin
金额：
$ 2.51万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591269/
关键词：
antidepressant stem cell hippocampus cortisol neuronal cell culture mood stabilizer neurotrophic factor MRI

项目摘要

1) The effect of stabilizers, antidepressants and monoamines to neural stem / progenitor cells derived from adult rat dentate gyrus.To evaluate the direct effect of stabilizers, antidepressants and monoamines to neurogenesis in the adult hippocampus, we established a culture system of neural stem / progenitor cells derived from adult rat dentate gyrus. Glucocorticoid of which serum level is increased under stress condition decreased a proliferation rate of the cells. On the contrary, both lithium and valproic acid recovered this glucocorticoid's effect. The β-catenin / TCF system was shown to play an important role in these stabilizer's action. On the other hand, antidepressants including SSRI and SNRI did not have any effects. Noradrenaline, but not serotonin, increased the cells thorough β 2 receptor with dose dependent manner. These results suggested antidepressants increased a hippocampal neurogenesis in various ways.2) The relationship between the activity of HPA axis and hippocam … More pal volume.There is compelling evidence for an important role of HPA axis abnormalities in the pathophysiology of mood disorders. Moreover, raised level of cortisol has been shown to produce the neuronal dysfunction of hippocampus with shrunken cell bodies in CA3 and decreased neurogenesis in dentate gyrus. In this study we investigated the relationship between the HPA abnormalities assessed with combined dexamethasone (DEX) / corticotropine-releasing hormone (CRH) test and hippocampal volume measured by manual segmentation on MRI in depressive patients. Significant enhanced pituitary-adrenocortical response to the DEX/CRH test were observed in depressive patients compared with controls. Moreover, hippocampal volume of patients was significantly decreased. The reduction was greater in 'nonsuppressor' who showed 〓 5μg/dl of cortisol concentration on any time points of combined DEX/CRH test compared with 'suppressors'. These results suggest that HPA axis abnormalities might be associated to the reduction of hippocampal volume in subjects suffered from mood disorder. Less

1)稳定剂、抗抑郁剂和单胺类药物对成年大鼠海马神经干/祖细胞的影响为了研究稳定剂、抗抑郁剂和单胺类药物对成年大鼠海马神经发生的直接影响，我们建立了成年大鼠海马神经干/祖细胞的培养体系。在应激条件下血清水平升高的糖皮质激素降低了细胞的增殖速率。相反，锂和丙戊酸都恢复了这种糖皮质激素的作用。β-catenin / TCF系统在这些稳定剂的作用中起重要作用。另一方面，包括SSRI和SNRI在内的抗抑郁药没有任何效果。去甲肾上腺素通过β_2受体增加细胞增殖，而5-羟色胺则无此作用，且呈剂量依赖性。提示抗抑郁药可通过多种途径促进海马神经元的发生。2）HPA轴活性与海马CA 1/CA 2的关系 ...更多信息有令人信服的证据表明HPA轴异常在情绪障碍的病理生理学中起重要作用。此外，皮质醇水平的升高已被证明产生海马的神经元功能障碍，其中CA 3中的细胞体萎缩，并且齿状回中的神经发生减少。在这项研究中，我们调查了抑郁症患者的HPA异常与联合地塞米松（DEX）/促肾上腺皮质激素释放激素（CRH）测试和海马体积手动分割测量的MRI之间的关系。与对照组相比，抑郁症患者的垂体-肾上腺皮质对DEX/CRH试验的反应显著增强。此外，患者的海马体积显著减小。与“抑制者"相比，在DEX/CRH联合试验的任何时间点，”非抑制者“的皮质醇浓度均> 5μg/dl。这些结果表明，HPA轴的异常可能与海马体积的减少，在受试者患有情绪障碍。少

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The relationship between the function of HPA axis and hippocampal volume.

HPA轴功能与海马体积的关系。

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
Matsuyama T;Nakagawa S;Kusumi I;Inoue T;Kudou K;Koyama T.
通讯作者：
Koyama T.

Effect of mood stabilizers for proliferation of neural stem/progenitorcells derived from adult rat dentate gyrus

情绪稳定剂对成年大鼠齿状回神经干/祖细胞增殖的影响

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
Shin Nakagawa;Shuken Boku;Takahiro Masuda;Hiroyuki Nishikawa;Akiko Kato;Yuji Kitaichi;Takeshi Inoue;Tsukasa Koyama
通讯作者：
Tsukasa Koyama

Effect of mood stabilizers for proliferation of neural stem / progenitor cells derived from adult rat dentate gyrus.

情绪稳定剂对成年大鼠齿状回神经干/祖细胞增殖的影响。