Neurophysiological study on cognitive pathology of depression : relevant to anterior cingulate cortex

抑郁症患者可能由于前扣带皮层的过度活跃而导致认知过程的失调。我们测量了反馈负性，事件相关脑电位和功能磁共振成像在强加决策和奖励预测问题，分别。与对照组相比，精神分裂症患者的负反馈幅度降低。使用功能性磁共振成像，奖励预测诱导健康受试者背侧前扣带皮层和腹侧纹状体神经元活动增加。进一步的研究正在进行中，以评估抑郁症患者的这些神经生理学指标。

It is possible that depressive patients have dysregulation of cognitive processes due to hyperactivity of anterior cingulate cortex. We measured feedback negativity, one of event-related brain potential and functional MRI during imposing decision-making and reward prediction problems, respectively. The amplitude of feedback negativity was decreased in schizophrenia patients compared to controls. Reward prediction induced increased neuronal activities in the dorsal anterior cingulate cortex and ventral striatum of healthy subjects using a functional MRI. Further studies are ongoing to evaluate these neurophysiological measures in depressed patients.