Role of neuroplastin in memory impairment in schizophrenia-A basic and clinical study

点击翻译按钮获取中文摘要

We investigated whether variations in single nucleotide polymorphism (SNPs) in 5,-upstream regions of genes encoding neuroplastin (NPTN) confer cognitive and memory function in schizophrenia. Subjects consisting of 207 schizophrenic patients and 262 unrelated control subjects were administered BACS-J, and a proxy measure of premorbid IQ by using Japanese Adult Reading Test. Patients performed significantly below controls on all domains of BACS-J. There was no effect of rs3840846 on any domain of BACS-J. Only in patients, but not controls, rs3826047 A/G carriers performed significantly worse in executive function than G/G carriers. Only in patients, but not controls, rs3743500 G/G carriers performed significantly worse in word memory and word fluency than G/T carriers. These data suggest that putative promoter region of the NPTN gene may be involved in impairment of word memory and executive function in schizophrenia.