Biological study of socialization deficit and psycho-social intervention in schizophrenia.

对精神危险状态（ARMS）、精神分裂症患者和健康人进行常规神经心理成套测验、磁共振成像（MRI）和事件相关电位（ERP）检查。富山大学附属医院与富山县精神卫生中心合作，在富山启动了ARMS咨询和支助服务。符合ARMS标准的31名客户中有3人随后出现了精神病的首次发作。神经心理学和ERP评估表明，ARMS受试者表现出介于健康受试者和精神分裂症患者之间的异常配置文件。功能磁共振成像显示精神分裂症患者杏仁核功能异常。首发精神分裂症的纵向MRI数据显示上级颞叶和额叶下部的灰质过度减少。

Conventional neuropsychological test battery, magnetic resonance imaging (MRI) and event related potential (ERP) were evaluated from subjects at risk mental state (ARMS), patients with schizophrenia and healthy subjects. The Consultation and Support service in Toyama (CAST) for ARMS was launched by the Toyama University Hospital in cooperation with the Toyama Prefectural Mental Health Centre. Three of 31 clients who met ARMS criteria have subsequently developed a first episode of psychosis. Neuropsychological and ERP evaluation showed that ARMS subjects manifest abnormal profiles intermediate between healthy subjects and schizophrenia patients. Functional-MRI study showed an anomalous amygdala function in the schizophrenia patients. Longitudinal MRI data of the first-episode schizophrenia indicated excessive gray matter decrease in the superior temporal and inferior frontal regions.