The relationship between the effect of rehabilitation and loss of neuronal integrity in patients with brain injury.

目的之一是利用SPECT和PET等分子成像技术分析苯二氮卓受体密度、代谢、神经元完整性的序列和空间变化。为了明确其序列变化，我们利用动物PET/SPECT/CT对动物C-11氟马西尼进行重建和分析。建立了一种利用大鼠模型分析C-11氟马西尼结合电位的新方法。另一个目的是探讨脑损伤患者的康复效果与神经元完整性的关系。首先，我们研究了C-11氟马西尼PET表现与I-123氟马西尼SPECT表现之间的关系。我们的研究表明，尽管IMZ SPECT的对比度略低于FMZ PET，但IMZ SPECT对神经元完整性丧失的检测效果与FMZ PET几乎相同。其次，我们研究代谢变化、神经元完整性丧失与康复效果之间的关系。然而，我们无法找到这些参数之间的关系。

One of the aims was to analyze the sequential and spatial change of benzodiazepine receptor density, metabolism, neuronal integrity using molecular imaging such as SPECT and PET. To clarify the sequential change, we investigate the reconstruction and analyzing method for animal C-11 flumazenil using animal PET/SPECT/CT. We developed a new method for analyzing binding potential of C-11 flumazenil using rat model. Another aim was to investigate the relationship between effect of rehabilitation and neuronal integrity in patients with brain injury. First we studied the relationship between C-11 flumazenil PET findings and I-123 Iomazenil SPECT findings. Our study indicated that although IMZ SPECT has slightly lower contrast than FMZ PET, IMZ SPECT could detect loss of neuronal integrity as almost same as FMZ PET. Second, we investigate the relationship among metabolic change, loss of neuronal integrity and effect of rehabilitation. However, we could not find the relationship among those parameters.