Application of new generation PET to brain tumor treatment strategy

新一代PET在脑肿瘤治疗策略中的应用

• 批准号: 23591744
• 负责人: SHIGA Tohru
• 金额: $ 3.24万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591744/
• 关键词: 機能イメージング; 脳腫瘍; 治療戦略; 機能ｲﾒｰｼﾞﾝｸﾞ

The purpose of this study was to reveal the usefulness of molecular imaging in strategy of brain tumor treatment. We used two technique for the purpose. One was to investigate relationships between molecular imaging and brain tumor pathology, another was to investigate the superiority of high spatial resolution and high energy resolution PET system in molecular imaging. We clarified that hypoxia imaging differentiated glioblastoma from other grade glioma and high spatial and energy resolution PET could produce high regression between FDG uptake and tumor proliferation.

本研究的目的是揭示分子影像学在脑肿瘤治疗策略中的作用。我们为此使用了两种技术。一是探讨分子影像学与脑肿瘤病理的关系，二是探讨高空间分辨率和高能量分辨率PET系统在分子影像学中的优越性。我们阐明了乏氧显像可将胶质母细胞瘤与其他级别胶质瘤区分开来，高空间和能量分辨率PET可使FDG摄取与肿瘤增殖高度回归。

项目成果

Optimization of energy window setting of the semiconductor PET for clinical FDG studies

用于临床 FDG 研究的半导体 PET 能量窗口设置的优化

• 发表时间: 2012
• 作者: Shiga T;Takeuchi W;Morimoto Y;Kubo N;Hirata K;Kobasi K;Hattori N;Tamaki N
• 通讯作者: Tamaki N