Evaluation of radiotoxicity to lymphocytes after Yttrium-90-labelled monoclonal anti-CD20 antibody therapy
Evaluation of radiotoxicity to lymphocytes after Yttrium-90-labelled monoclonal anti-CD20 antibody therapy
批准号:
20591435
负责人:
WATANABE Naoto
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
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英文摘要
The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes in malignant lymphoma after Y-90 therapy usingγ-H2AX foci immunodetection. This study focused on a patient who underwent Y-90 therapy for malignant lymphoma. Venous blood samples were collected from each patient. Lymphocytes were isolated from the blood samples and subjected toγ-H2AX immunofluorescence staining. The number of foci per lymphocyte nucleus was increased after Y-90 therapy.γ-H2AX foci immunodetection in lymphocytes may detect radiation-induced DNA damage associated with Y-90 therapy of malignant lymphoma.
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会议论文
アイソトープ治療におけるリンパ球の放射線障害評価に関する検討
同位素治疗过程中淋巴细胞放射损伤评价研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shibata K, Arai M, Matsuura M, Uno K, Yoshida T, Momose T, Ohtomo K, 道合万里子]
通讯作者:
道合万里子
アイソトープ治療におけるリンパ球の放射線組織障害評価に関する検討
同位素治疗过程中放射性组织对淋巴细胞损伤评价的研究
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[道合万里子, 渡邉直人, 髙橋知子, 谷口充, 利波久雄, 岩淵邦芳, 萱野大樹, 福岡誠, 絹谷清剛]
通讯作者:
絹谷清剛
アイソトープ治療におけるリンパ球の放射線組織障害評価に関する基礎的検討
同位素治疗中淋巴细胞放射损伤评价的基础研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[道合万里子, 高橋知子, 谷口充, 渡邉直人, 利波久雄, 絹谷清剛]
通讯作者:
絹谷清剛
Evaluation of radiotoxicity after Ra-223 therapy using gamma-H2AX foci formation in lymphocytes.
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批准号:16K10366
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2016
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负责人:WATANABE Naoto
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依托单位:
Evaluation of radiotoxicity after iodine-131 therapy using DNA damage in lymphocytes
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批准号:24591794
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:WATANABE Naoto
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依托单位:
Empirical Analysis of the Motivational Effects of Strategic Communication Using the Balanced Scorecard in Japanese Hospitals
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批准号:21730384
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资助金额:$2.5万
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财政年份:2009
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依托单位:
Radiotoxicity after iodine-131 MIBG therapy using the micronucleus assay
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批准号:17591251
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.52万
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财政年份:2005
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负责人:WATANABE Naoto
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依托单位:
Evaluation of radiotoxicity after strontium-89 therapy for bone metastases using the micronucleus assay.
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批准号:12670857
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:WATANABE Naoto
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依托单位:
Radiotoxicity after iodine-131 therapy for thyroid cancer using the micronucleus assay
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批准号:08671009
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.54万
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财政年份:1996
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负责人:WATANABE Naoto
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依托单位: