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Evaluation of radiotoxicity to lymphocytes after Yttrium-90-labelled monoclonal anti-CD20 antibody therapy

Evaluation of radiotoxicity to lymphocytes after Yttrium-90-labelled monoclonal anti-CD20 antibody therapy
钇90标记单克隆抗CD20抗体治疗后淋巴细胞放射毒性评价
批准号:
20591435
负责人:
WATANABE Naoto
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011

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中文摘要
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英文摘要
The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes in malignant lymphoma after Y-90 therapy usingγ-H2AX foci immunodetection. This study focused on a patient who underwent Y-90 therapy for malignant lymphoma. Venous blood samples were collected from each patient. Lymphocytes were isolated from the blood samples and subjected toγ-H2AX immunofluorescence staining. The number of foci per lymphocyte nucleus was increased after Y-90 therapy.γ-H2AX foci immunodetection in lymphocytes may detect radiation-induced DNA damage associated with Y-90 therapy of malignant lymphoma.
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アイソトープ治療におけるリンパ球の放射線障害評価に関する検討
同位素治疗过程中淋巴细胞放射损伤评价研究
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Shibata K, Arai M, Matsuura M, Uno K, Yoshida T, Momose T, Ohtomo K, 道合万里子]
通讯作者: 道合万里子
アイソトープ治療におけるリンパ球の放射線組織障害評価に関する検討
同位素治疗过程中放射性组织对淋巴细胞损伤评价的研究
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [道合万里子, 渡邉直人, 髙橋知子, 谷口充, 利波久雄, 岩淵邦芳, 萱野大樹, 福岡誠, 絹谷清剛]
通讯作者: 絹谷清剛
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [道合万里子, 高橋知子, 谷口充, 渡邉直人, 利波久雄, 絹谷清剛]
通讯作者: 絹谷清剛
Evaluation of radiotoxicity after Ra-223 therapy using gamma-H2AX foci formation in lymphocytes.
  • 批准号:
    16K10366
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2016
  • 负责人:
    WATANABE Naoto
  • 依托单位:
Evaluation of radiotoxicity after iodine-131 therapy using DNA damage in lymphocytes
  • 批准号:
    24591794
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.41万
  • 财政年份:
    2012
  • 负责人:
    WATANABE Naoto
  • 依托单位:
Empirical Analysis of the Motivational Effects of Strategic Communication Using the Balanced Scorecard in Japanese Hospitals
  • 批准号:
    21730384
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.5万
  • 财政年份:
    2009
  • 负责人:
    WATANABE Naoto
  • 依托单位:
Radiotoxicity after iodine-131 MIBG therapy using the micronucleus assay
  • 批准号:
    17591251
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.52万
  • 财政年份:
    2005
  • 负责人:
    WATANABE Naoto
  • 依托单位: