Serial alteration of cerebral blood flow and glucose metabolism before and after the non-smoking therapy in young men with smoking habit

有吸烟习惯的青年男性戒烟治疗前后脑血流及糖代谢的系列变化

• 批准号: 20591452
• 负责人: NAGAMACHI Shigeki
• 金额: $ 3.08万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591452/
• 关键词: 喫煙; 禁煙治療; FDG-PET; CT; 脳血流SPECT; SPM; 3D-SRT解析; FDG-PET/CT; SPM解析; 3DSRT解析

Chronic cigarette smoking is known to be associated with decrease of regional cerebral blood flow (rCBF).The aim of this study was to evaluate the serial alteration of rCBF and cerebral glucose metabolism pre and post cessation of smoking therapy in younger healthy men. Ten young male smokers (aged 21-26 years, mean age 21.5 years) with a smoking habit were recruited. None of the subjects had a history of any neurological disorder. We evaluated the serial change of regional cerebral blood flow and glucose metabolism before and after non-smoking therapy. ^<99m>Tc-SPECT was used to evaluate rCBF distribution and ^<18>F-FDG PET was used to evaluate cerebral glucose metabolisms in both at baseline (during smoking) and after they had quit smoking. After non- smoking therapy, rCBF significantly increased compared with those at baseline condition in left frontal lobe, left temporal lobe, around central sulcus, lenticular nuclei and right thalamus. Similarly, FDG uptake increased significantly, in the left middle temporal gyrus and the left middle inferior gyrus after non-smoking therapy. In conclusion, non-smoking therapy increased rCBF and glucose uptake in young men with smoking habit.

本研究旨在探讨年轻健康男性戒烟前后局部脑血流量（rCBF）和脑葡萄糖代谢的变化。招募了10名有吸烟习惯的年轻男性吸烟者（年龄21-26岁，平均年龄21.5岁）。所有受试者均无任何神经系统疾病史。观察戒烟前后局部脑血流及糖代谢的动态变化。用~ 1 <99m>Tc-SPECT评估吸烟前和戒烟后的rCBF分布，用~ <18>1F-FDGPET评估脑葡萄糖代谢。戒烟治疗后，左侧额叶、左侧颞叶、中央沟周围、豆状核、右侧丘脑rCBF较治疗前明显升高。同样，不吸烟治疗后，左侧颞中回和左侧中下回的FDG摄取显著增加。总之，非吸烟治疗增加了吸烟青年男性的rCBF和葡萄糖摄取。

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