Analyses of catecholamine system in depression and schizophrenia by using neuromelanin magnetic resonance imaging
Analyses of catecholamine system in depression and schizophrenia by using neuromelanin magnetic resonance imaging
批准号:
20591458
负责人:
SASAKI Makoto
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We investigated signal changes in catecholamine nuclei of the brain stem by using neuromelanin- sensitive magnetic resonance imaging (MRI). In the depressive patients, signal intensity of the locus ceruleus was attenuated as compared with schizophrenic patients and healthy controls with high sensitivity and specificity, suggesting hypofunction of the noradrenergic system. In schizophrenia, signals from the substantia nigra pars compacta tended to be augmented and those from the ventral tegmental area tended to be reduced, suggesting dysfunction of the dopaminergic system. Neuromelanin MRI is a promising technique to elucidate functional changes in the catecholamine neurons of the brain stem that occur in psychiatric diseases.
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Neuromelanin MR imaging in neuropsychiatric disorders
神经黑色素 MR 成像在神经精神疾病中的应用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Niitsu M, Matsuzaki M, Aoki T, 佐々木真理, Sasaki M]
通讯作者:
Sasaki M
脳神経領域における動態イメージングの現状と将来
颅神经领域动态成像的现状与未来
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shimizu Y, Umeda M, Aoki I, Higuchi T, Tanaka C, et al.(6人、6番目), 佐々木真理]
通讯作者:
佐々木真理
Naidich TP (ed) Duvernoy's Atlas of the Human Brain Stem and Cerebellum
Naidich TP (ed) Duvernoy 的人类脑干和小脑图谱
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shibata E, Sasaki M]
通讯作者:
Sasaki M
精神神経疾患のイメージング-形態画像の基礎
神经精神疾病的成像 - 形态学成像的基础知识
DOI:
--
发表时间:
2009
期刊:
臨床放射線 54
影响因子:
--
作者:
[Kawai Y, Aoki I, Umeda M, Higuchi T, Tanaka C, et al. (8人、8番目), 新津守, Sasaki M]
通讯作者:
Sasaki M
Advanced neuroimaging using high field MRI.
使用高场 MRI 进行先进的神经成像。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Okamoto Y, Kunimatsu A, Miki S, Shindo M, Niitsu M, 成瀬昭二, 佐々木真理]
通讯作者:
佐々木真理
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