The Y-box binding protein-1 (YB-1) functions in various biological processes, including transcriptional and translational control, DNA repair, drug resistance, and cell proliferation in gastrointestinal malignancies.

真核生物Y-box结合蛋白-1（YB-1）在转录和翻译调控、DNA修复、耐药性和细胞增殖等生物学过程中发挥重要作用。与YB-1+/+细胞相比，YB-1 +/+细胞对顺铂和丝裂霉素C的敏感性增加，但对足叶乙甙、X射线或紫外线照射的敏感性不增加。YB-1可能具有对DNA损伤剂的细胞毒性作用发挥保护作用的能力，并且可能涉及耐药性的某些方面。

The eukaryotic Y-box binding protein-1 (YB-1) functions in various biological processes, includingtranscriptional and translational control, DNA repair, drug resistance, and cell proliferation. YB-1+/cells showed increased sensitivity to cisplatin and mitomycin C, but not to etoposide, X-ray or UV irradiation, as compared to YB-1+/+cells. YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance.