Establishment of novel treatment strategy based on the biological characteristics of esophageal squamous cell carcinoma.

根据食管鳞癌的生物学特性建立新的治疗策略。

• 批准号: 20591582
• 负责人: HANAGIRI Takeshi
• 金额: $ 3.08万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591582/
• 关键词: 食道癌; 扁平上皮癌; ERalpha; ERbeta; 抗腫瘍効果; topoisomerase-I; topoisomerase-II; HLA

In this study, expression of topoisomerase-I, topoisomerase-IIα, and HLA class I was investigated for establishment of novel treatment strategy for patients with esophageal cancer. The positive expression of topoisomerase-I was identified in 62% of the patients, and the expression of topoisomerase-I was not prognostic factor. The positive expression of topoisomerase-IIαwas observed in 62% of the patients, and the patients with positive expression of topoisomerase-IIαhad a tendency of favorable prognosis. The positive expression of HLA class I showed a tendency of favorable prognosis.

在本研究中，研究了拓扑异构酶-I、拓扑异构酶-IIα和HLA I类的表达，以建立食管癌患者的新治疗策略。 62%的患者拓扑异构酶-I阳性表达，拓扑异构酶-I的表达不是预后因素。 62%的患者拓扑异构酶-IIα阳性表达，拓扑异构酶-IIα阳性表达的患者预后良好。 HLA I类阳性表达提示预后良好的趋势。

项目成果

食道扁平上皮癌におけるα、β、γカテニン発現の意義

α、β、γ-连环蛋白在食管鳞癌中表达的意义

• 发表时间: 2008
• 作者: 肥田圭介;高橋正統;千葉丈広;岩谷岳;木村祐輔;西塚哲;新田浩幸;大塚幸喜;柏葉匡寛;佐々木章;水野大;若林剛;S-1/CDDP 術前化学療法中に重篤な骨髄抑制を生じた進行胃癌の1例;Miyake T;野添忠浩
• 通讯作者: 野添忠浩

Expression of cytochrome P450 in non-small cell lung cancer.

• DOI: 10.2741/3116
• 发表时间: 2008-05
• 期刊: Frontiers in bioscience : a journal and virtual library
• 作者: T. Oyama;K. Sugio;T. Isse;A. Matsumoto;N. Nose;H. Uramoto;T. Nozoe;M. Morita;N. Kagawa;T. Osaki;M. Muto;K. Yasumoto;T. Kawamoto

Association Between Estrogen Receptor-{beta} Expression and Epidermal Growth Factor Receptor Mutation in the Postoperative Prognosis of Adenocarcinoma of the Lung

雌激素受体-{β}表达与表皮生长因子受体突变与肺腺癌术后预后的关系

• 发表时间: 2009
• 期刊: J Clin Oncol 27(3)
• 作者: Yamaue H;et al.;川井 学;谷 眞至;東口 崇;山上 裕機;山上 裕機;山上 裕機;山上 裕機;山上 裕機;山上 裕樹;山上 裕機;Nose N
• 通讯作者: Nose N

Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid

• DOI: 10.1111/j.1442-2050.2007.00725.x
• 发表时间: 2008-01-01
• 期刊: DISEASES OF THE ESOPHAGUS
• 影响因子: 2.6
• 作者: Morita, M.;Yoshida, R.;Maehara, Y.
• 通讯作者: Maehara, Y.

Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations

• DOI: 10.1016/j.lungcan.2008.09.010
• 发表时间: 2009-06-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Sugio, Kenji;Uramoto, Hidetaka;Yasumoto, Kosei
• 通讯作者: Yasumoto, Kosei