Clinical Significance of Regulatory T Cells in Regional Lymph Node Lymphocytes of Non-Small-Cell Lung Cancer and overcoming immune-escape mechanism

点击翻译按钮获取中文摘要

Regulatory T cells (Tregs) are potent immunosuppressive cells that play a crucial role in tumor immune escape. The purpose of the present study was to evaluate the prognostic significance of CD4+ CD25+ Foxp3+ Tregs in the regional lymph node lymphocytes (RLNL) in patients who underwent surgical resection of non-small cell lung cancer (NSCLC). The proportions of Tregs in the RLNL were determined by flow cytometry and quantitative RT–PCR. The 5-year survival rate was significantly better in patients with the lower proportion of Tregs than that in the higher patients. The higher proportion of Tregs in the RLNL was a significant unfavorable prognostic factor in NSCLC. The information about the proportion of Tregs in the RLNL is considered to be important to overcome the tumor immune escape for development of the effective adjuvant immunotherapy