Clinical Significance of Regulatory T Cells in Regional Lymph Node Lymphocytes of Non-Small-Cell Lung Cancer and overcoming immune-escape mechanism

非小细胞肺癌区域淋巴结淋巴细胞调节性T细胞及克服免疫逃逸机制的临床意义

• 批准号: 23592079
• 负责人: HANAGIRI Takeshi
• 金额: $ 3.24万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592079/
• 关键词: 肺癌; 制御性T細胞; 腫瘍免疫; 免疫逃避; 細胞障害性T細胞; 免疫逃避機構; 制御性Ｔ細胞; TGF-β; Foxp3; 所属リンパ節; 制御性Tリンパ球; フローサイトメトリ; リアルタイムPCR

Regulatory T cells (Tregs) are potent immunosuppressive cells that play a crucial role in tumor immune escape. The purpose of the present study was to evaluate the prognostic significance of CD4+ CD25+ Foxp3+ Tregs in the regional lymph node lymphocytes (RLNL) in patients who underwent surgical resection of non-small cell lung cancer (NSCLC). The proportions of Tregs in the RLNL were determined by flow cytometry and quantitative RT–PCR. The 5-year survival rate was significantly better in patients with the lower proportion of Tregs than that in the higher patients. The higher proportion of Tregs in the RLNL was a significant unfavorable prognostic factor in NSCLC. The information about the proportion of Tregs in the RLNL is considered to be important to overcome the tumor immune escape for development of the effective adjuvant immunotherapy

调节性T细胞（Regulatory T cells，TCFs）是一种免疫抑制细胞，在肿瘤免疫逃逸中起重要作用。本研究旨在探讨非小细胞肺癌（NSCLC）患者手术切除术后局部淋巴结（RLNL）中CD 4 + CD 25 + Foxp 3 + T淋巴细胞的表达与预后的关系。流式细胞术和定量RT-PCR测定RLNL中TlR的比例。低TNM分期患者的5年生存率明显高于高TNM分期患者。RLNL中较高比例的TcB是NSCLC的一个显著不良预后因素。因此，了解肿瘤淋巴细胞中TGFAP的比例，对于克服肿瘤免疫逃逸，开发有效的辅助免疫治疗具有重要意义

项目成果

Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer

• DOI: 10.1016/j.jss.2012.07.029
• 发表时间: 2013-05-15
• 期刊: JOURNAL OF SURGICAL RESEARCH
• 影响因子: 2.2
• 作者: Hanagiri, Takeshi;Shigematsu, Yoshiki;Tanaka, Fumihiro
• 通讯作者: Tanaka, Fumihiro