The protective effect of percutaneous isolated hepatic perfusion on high-risk group for the recurrence of Hepatocellular carcinoma after resection

经皮离体肝灌注对高危人群肝细胞癌术后复发的保护作用

• 批准号: 20591611
• 负责人: KU Yonson
• 金额: $ 2.75万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591611/
• 关键词: 肝細胞癌; 再発肝癌; 経皮的肝灌流化学療法; 肝内再発; 肝切除; 経皮的肝灌流

Hepatic resection remains the only therapeutic option for improved survival in the patients with hepatocellular carcinoma (HCC). However, a high incidence of recurrence after resection is life-threatening problem. In this study, we proposed percutaneous isolated hepatic perfusion (PIHP), a novel and potent regional chemotherapeutic regimen can achieve the protection against high-risk group for the recurrence of HCC after resection. PIHP after hepatic resection improved overall survival. In conclusion, dual treatment of resection and PIHP can offer an innovative strategy for resectable HCC treatment.

肝切除术仍然是提高肝细胞癌（HCC）患者生存率的唯一治疗选择。然而，切除术后复发率高是危及生命的问题。在这项研究中，我们提出了经皮隔离肝灌注（PIHP），一种新的和有效的区域化疗方案，可以实现对肝癌切除术后复发的高危人群的保护。肝切除术后PIHP改善了总生存率。总之，切除和PIHP的双重治疗可以为可切除的HCC治疗提供创新策略。

项目成果

A focal mass-forming autoimmune pancreatitis mimicking pancreatic cancer with obstruction of the main pancreatic duct.

• DOI: 10.1007/s11605-011-1543-5
• 发表时间: 2011-12
• 期刊: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
• 作者: Matsumoto I;Shinzeki M;Toyama H;Asari S;Goto T;Yamada I;Ajiki T;Fukumoto T;Ku Y
• 通讯作者: Ku Y

Clinical Results and Risk Factors of Proton and Carbon Ion Therapy for Hepatocellular Carcinoma

• DOI: 10.1002/cncr.26134
• 发表时间: 2011-11-01
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Komatsu, Shohei;Fukumoto, Takumi;Murakami, Masao
• 通讯作者: Murakami, Masao

肝胆膵

肝脏、胆汁、胰腺

• 作者: 米村和紘・小山内康人;ほか;竹門康弘(分担執筆);澁谷 景子
• 通讯作者: 澁谷 景子

膵臓の内視鏡外科手術

内窥镜胰腺手术

• 发表时间: 2010
• 作者: 丸山通広;他;丸山通広;丸山通広
• 通讯作者: 丸山通広

腫瘍栓の外科治療 切除のコツと予後からみた適応

癌栓的手术治疗：基于预后的切除技巧和适应证

• 发表时间: 2008
• 期刊: 外科 70
• 作者: Shinkawa H;Kubo S;et al.;岩崎 武;木戸 正浩
• 通讯作者: 木戸 正浩