Improvement of peptide induced CTL therapy against malignant glioma by HDAC inhibitor

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We found three new peptides binding HLA-A24 which could induce CTLs against malignant gliomas. Furthermore, VPA, valproic acid, which have an activity of HDAC, histone deacetylase, inbibitor could enhance the expression of HLA on the surface of a glioma cell line YKG-1. CTL activity was also enhanced by VPA application. VPA is known as an anticonvulsant and can pass through a blood brain barrier into brain. If immunotherapy against malignant glioma is undergone to patients who are needed with antiepileptic drug application, VPA might be recommended.