Gene therapy for treatment of pulmonary hypertension using plasmid vector

点击翻译按钮获取中文摘要

We found decreased expression of neuropeptide VIP, PACAP and decreased expression of their receptors in lung of monocrotaline-induced pulmonary hypertension in rat. It was assumed that the receptor might be induced to compensate for the decrease of VIP and PACAP. Thus, we hypothesized that induction of PACAP in lung could improve pulmonary hypertension. To examine the hypethesis, we created PACAP encoding plasmid and lentivirus vectors and examined the way to introduce them to the lung.