calcium sensitization in pulmoary hypertension

肺动脉高压中的钙敏化

• 批准号: 23592304
• 负责人: MIZUNO Yusuke
• 金额: $ 3.33万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592304/
• 关键词: 肺高血圧症; MLCK; リン酸化; desensitization; ＭＬＣＫ; CPI-17; pulmonary hypertension; 肺血管平滑筋

In this study, we found the involvement of imparied calcium desensitization mechanism of MLCK by phosphorylation of MLCK in pulmoanry hypertension in rats. It is well known that calcium sensitization occured during vascular contraction and in hyper-vasocontractile diseases. However, calcium desensitization mechanism in vasucura diseases is little known. The understanding of the desensitization mechanism may provide novel therapy for pulmonary hypertension.

本研究发现大鼠肺动脉高压中MLCK的磷酸化参与了MLCK的钙脱敏受损机制。众所周知，钙敏化发生在血管收缩和血管过度收缩疾病中。然而，钙脱敏在血管疾病中的作用机制尚不清楚。了解脱敏机制可能为肺动脉高压的治疗提供新的思路。

项目成果

Involvement of increased protein arginine methyltransferases 2 and decreased dimethylarginine dimethylaminohydrolases in impaired NOS activity in pulmonary hypertension in rats

蛋白精氨酸甲基转移酶 2 增加和二甲基精氨酸二甲氨基水解酶减少与肺动脉高压大鼠 NOS 活性受损有关

• 发表时间: 2013
• 作者: Ｙｕｓｕｋｅ Ｍｉｚｕｎｏ;Ｈｉｒｏｎｏｂｕ Ｓｈｉｎｂｏｒｉ， Ｔａｋａｈｉｓａ Ｇoto
• 通讯作者: Ｈｉｒｏｎｏｂｕ Ｓｈｉｎｂｏｒｉ， Ｔａｋａｈｉｓａ Ｇoto

Effect of VPAC2 Agonist on Improving Cardiac Output

VPAC2 激动剂对改善心输出量的影响

• 发表时间: 2013
• 作者: Yusuke Mizuno;Motokazu Koga;Shizuka Kashiwagi;Itaru Watanabe;Takahisa Goto
• 通讯作者: Takahisa Goto