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Pharmacologic plasticity of analgesic drugs in neuropathic pain states-measurement with monoamines in the spinal cord-

Pharmacologic plasticity of analgesic drugs in neuropathic pain states-measurement with monoamines in the spinal cord-
镇痛药物在神经病理性疼痛状态下的药理可塑性-脊髓中单胺的测量-
批准号:
20591823
负责人:
OBATA Hideaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We examined mechanisms of antinociceptive effects of drugs such as antidepressant and gabapentin for neuropathic pain using rat pain models. We also measured spinal noradrenalin and serotonin level after the drug injection using microdialysis. We demonstrated that these drugs increased noradrenalin level in the spinal cord and the noradrenalin increase strongly contributed to the inhibitory effect for neuropathic pain.
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会议论文
A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain
新型 bFGF-GH 注射疗法治疗两例严重缺血性肢体疼痛患者
DOI: --
发表时间:
期刊: Journal of Anesthesia 22
影响因子: --
作者: [Ito N, Saito S, Yamada MH, Koizuka S,Obata H, Nishikawa K, Tabata Y]
通讯作者: Tabata Y
末梢の急性炎症に対する5-HTの作用機序
5-HT对急性外周炎症的作用机制
DOI: --
发表时间: 2009
期刊: 生体の科学 60
影响因子: --
作者: [Kato H, Tokuda H, et al., 小幡英章]
通讯作者: 小幡英章
Long-term effect of slow releasing lidocaine sheet and particle in a rat model of postoperative pain.
缓释利多卡因片和颗粒对术后疼痛大鼠模型的长期影响。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Suto T, Tobe H, Obata H, Saito S, Goto F.]
通讯作者: Goto F.
Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model.
术后疼痛模型中的脊髓小胶质细胞表达和机械过敏。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Obata H, Ito N, Saito S.]
通讯作者: Saito S.
36
    Pharmacological mechanisms of locus coeruleus activation -recruitment of descending inhibition for treatment of neuropathic pain-
    • 批准号:
      24659691
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2012
    • 负责人:
      OBATA Hideaki
    • 依托单位:
    Mechanisms of effective drugs for management of neuropathic pain relationship between activation of descending inhibitory systems and pharmacologic plasticity
    • 批准号:
      23390373
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2011
    • 负责人:
      OBATA Hideaki
    • 依托单位:
    The clarification of quantitative measurement and the management index at the time of a pumpless extracorporeal respiratory assist device use
    • 批准号:
      20500431
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2008
    • 负责人:
      OBATA Hideaki
    • 依托单位:
    Possible involvement of activation of spinal glia with chronic pain
    • 批准号:
      17591613
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      OBATA Hideaki
    • 依托单位:
    海外基金