Is angiogenesis in regenerative medicine influenced by anesthetics and perioperative management methods?

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We examined the influence of various anesthetics on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of the inhalation anesthetic should be less, and basic experiments using cultured cells indicated part of the intravenous anesthetic tended to promote angiogenesis. It is hoped that a new indicator of the perioperative administration is established by the influence of the anesthetic which gives it to angiogenesis being elucidated.