Is angiogenesis in regenerative medicine influenced by perioperative management methods? -effect of hyperglycemia-

我们在动物实验、临床研究和使用培养细胞的基础实验中研究了围手术期管理方法，特别是血糖控制对血管生成的影响。动物实验和临床研究表明，急性高血糖对血管生成的影响较小，但培养细胞的基础实验表明，高血糖有抑制血管生成的趋势。希望通过阐明血糖控制对血管生成的影响，建立围手术期给药的新指标。

We examined the influence of perioperative management methods, especially glycemic control on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of acute hyperglycemia should be less, however, basic experiments using cultured cells indicated hyperglycemia tended to inhibit angiogenesis. It is hoped that a new indicator of the perioperative administration is established by the influence of glycemic control which gives it to angiogenesis being elucidated.