The search of the prostate cancer marker based on blood carbohydrate chain structure and the establishment of the diagnostic method
The search of the prostate cancer marker based on blood carbohydrate chain structure and the establishment of the diagnostic method
批准号:
20591867
负责人:
FUJIMURA Tsutomu
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Postate-specific antigen (PSA) has been widely used for detection and diagnosis of prostate cancer. But a false-positive is high in the diagnosis of the prostate cancer when I use PSA. I compared glycosylation haptoglobin as a prostate cancer marker as alternated PSA. The sialylation and fucosylation of the haptoglobin significantly rose with prostate cancer serum .I showed the possibility of a diagnostic method used as tumor marker of the novel prostate cancer that haptoglobin was based on blood carbohydrate structure.
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Glycosylation status of haptoglobin in sera of patients with prostate cancer versus benign prostate disease and normal subjects.
前列腺癌患者与良性前列腺疾病和正常受试者血清中触珠蛋白的糖基化状态。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Fujimura T., Shinohara Y., Hakomori S.]
通讯作者:
Hakomori S.
DOI:
10.4161/auto.7.7.15371
发表时间:
2011-07-01
期刊:
AUTOPHAGY
影响因子:
13.3
作者:
[Ezaki, Junji, Matsumoto, Naomi, Ueno, Takashi]
通讯作者:
Ueno, Takashi
DOI:
10.1248/bpb.32.345
发表时间:
2009-03-01
期刊:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子:
2
作者:
[Kawano, Tasuku, Sugawara, Shigeki, Nitta, Kazuo]
通讯作者:
Nitta, Kazuo
Identification of nitrotryptophan in the sequence of nitrated proteins generated by the treatment of PC12 cell lysate with peroxynitrite
用过亚硝酸盐处理 PC12 细胞裂解物产生的硝化蛋白序列中硝基色氨酸的鉴定
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Hiroaki K., Tsutomu F., Fumiyuki Y.]
通讯作者:
Fumiyuki Y.
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 13 条
Development of prostate cancer diagnostic marker targeting glycosylation
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批准号:26430145
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
-
财政年份:2014
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负责人:FUJIMURA Tsutomu
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依托单位:
Early diagnosis of prostate cancer using cancer-specific the glycosylated peptide antibody
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批准号:23592350
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2011
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负责人:FUJIMURA Tsutomu
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依托单位:
海外基金