New Model of BPH with Slowly Advancing Obstruction to Investigate Pathophysiology and Mechanism of Obstructed Bladder

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In the present study, using beagle dogs, we created a new animal model of benign prostatic obstruction, in which prostate would occlude the bladder outlet as prostate grows. This model showed urinary frequency, an increase in detrusor pressure during voiding and a mild degree of residual volume, which resembles a micturition behavior of patients with benign prostatic hyperplasia (BPH). In the obstructed bladder of this new model, the expression of smooth muscle growth factor (HB-EGF) was higher than that of fibrous growth factor such as TGF-β1while smooth muscle cell apoptosis was suppressed. These results suggest that compensatory muscle hypertrophy or hyperplasia may serve to sustain the ability of detrusor to contract.