Research for establishment of prevention for urolithiasis by considering metabolic syndrome

考虑代谢综合征建立尿石症预防措施的研究

• 批准号: 20591885
• 负责人: ITOH Yasunori
• 金额: $ 3万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591885/
• 关键词: 尿路結石症; メタボリックシンドローム; アディポサイトカイン; ストレス感受性シグナル; オステオポンチン; 結石モデルマウス; OPNノックアウトマウス; OPNトランスジェニックマウス; 酸化ストレス

Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.

尿石症在发生机制上类似于代谢综合征。然后，我们从遗传和环境因素考虑代谢综合征，进行了建立预防尿石症的研究。在遗传学研究中，我们分析了OPN基因的SNPs，并将其结果与患者的背景和结石成分进行了比较。我们发现特异性SNPs是结石复发的风险标记。在环境研究中，我们发现NFκB作为一种应激感受性信号，在氧化应激条件下增加，线粒体受到损伤。

项目成果

Effects of microgravity enhancement of oxidative stress in human renal tubular cells.

微重力增强人肾小管细胞氧化应激的影响。

• 发表时间: 2009
• 作者: Itoh Yasunori;Yasui Takahiro;Okada Atsushi;Hirose Masahito;Hamamoto Shuzo;Tozawa Keiichi;Hayashi Yutaro;Kohri Kenjiro
• 通讯作者: Kohri Kenjiro

NF-κB activation in renal tubular epithelial cells by oxalate stimulation

• DOI: 10.1111/j.1442-2042.2008.02131.x
• 发表时间: 2008-10-01
• 期刊: INTERNATIONAL JOURNAL OF UROLOGY
• 影响因子: 2.6
• 作者: Tozawa, Keiichi;Yasui, Takahiro;Kohri, Kenjiro
• 通讯作者: Kohri, Kenjiro

Genome-Wide Analysis of Genes Related to Kidney Stone Formation and Elimination in the Calcium Oxalate Nephrolithiasis Model Mouse: Detection of Stone-Preventive Factors and Involvement of Macrophage Activity

• DOI: 10.1359/jbmr.081245
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Okada, Atsushi;Yasui, Takahiro;Kohri, Kenjiro
• 通讯作者: Kohri, Kenjiro

Genome-wide association study identifies new susceptibility loci for urolithiasis.

全基因组关联研究确定了尿石症的新易感位点。

• 发表时间: 2009
• 作者: Usami Masayuki;Itoh Yasunori;Tozawa Keiichi;Matsuda Koichi;Nakamura Yusuke;Kohri Kenjiro
• 通讯作者: Kohri Kenjiro

尿路結石症。慢性腎臓病 : CKD最新の診療、モダンフィジシャン

尿石症。

• 发表时间: 2008
• 作者: 伊藤恭典;郡健二郎
• 通讯作者: 郡健二郎