Research for establishment of prevention for urolithiasis by considering metabolic syndrome
Research for establishment of prevention for urolithiasis by considering metabolic syndrome
批准号:
20591885
负责人:
ITOH Yasunori
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.
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Effects of microgravity enhancement of oxidative stress in human renal tubular cells.
微重力增强人肾小管细胞氧化应激的影响。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Itoh Yasunori, Yasui Takahiro, Okada Atsushi, Hirose Masahito, Hamamoto Shuzo, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro]
通讯作者:
Kohri Kenjiro
DOI:
10.1111/j.1442-2042.2008.02131.x
发表时间:
2008-10-01
期刊:
INTERNATIONAL JOURNAL OF UROLOGY
影响因子:
2.6
作者:
[Tozawa, Keiichi, Yasui, Takahiro, Kohri, Kenjiro]
通讯作者:
Kohri, Kenjiro
DOI:
10.1359/jbmr.081245
发表时间:
2009-05-01
期刊:
JOURNAL OF BONE AND MINERAL RESEARCH
影响因子:
6.2
作者:
[Okada, Atsushi, Yasui, Takahiro, Kohri, Kenjiro]
通讯作者:
Kohri, Kenjiro
Genome-wide association study identifies new susceptibility loci for urolithiasis.
全基因组关联研究确定了尿石症的新易感位点。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Usami Masayuki, Itoh Yasunori, Tozawa Keiichi, Matsuda Koichi, Nakamura Yusuke, Kohri Kenjiro]
通讯作者:
Kohri Kenjiro
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[伊藤恭典, 郡健二郎]
通讯作者:
郡健二郎
共 49 条
Cross sectional study from gene and environmental factor towards
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批准号:23592374
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:ITOH Yasunori
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依托单位:
海外基金