Cross sectional study from gene and environmental factor towards

从基因和环境因素的横断面研究

• 批准号: 23592374
• 负责人: ITOH Yasunori
• 金额: $ 3.33万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592374/
• 关键词: 尿路結石症; メタボリックシンドローム; アディポサイトカイン; ストレス感受性シグナル; オステオポンチン; 結石モデルマウス; OPNノックアウトマウス; OPNトランスジェニックマウス; 酸化ストレス; トランスジェニックマウス; DNAマイクロアレイ

Urolitiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and comared their results to patients background and stome composition.We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NF kappa B as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.

尿石症的发生机制类似于代谢综合征。然后，我们从遗传和环境因素考虑代谢综合征，进行了建立预防尿石症的研究。在遗传学研究中，我们分析了OPN基因的SNPs，并将其结果与患者背景和结石组成进行了比较，我们发现了特异性SNPs作为结石复发的风险标志。在环境研究中，我们发现NF-κ B作为一种应激感受性信号，在氧化应激条件下增加，线粒体受到损伤。

项目成果

Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice

• DOI: 10.1007/s00240-011-0400-z
• 发表时间: 2012-04-01
• 期刊: UROLOGICAL RESEARCH
• 作者: Hirose, Masahito;Tozawa, Keiichi;Kohri, Kenjiro
• 通讯作者: Kohri, Kenjiro

Administration of the selective alpha 1A adrenoceptor antagonist silodosin facilitates expulsion of 1.5mm or larger distal ureteral stones, as compared to control

与对照相比，施用选择性 α1A 肾上腺素受体拮抗剂西洛多辛有助于排出 1.5 毫米或更大的远端输尿管结石

• 发表时间: 2012
• 作者: Yasunori Itoh;Atsushi Okada;Masahito Hirose;Shuzo Hamamoto;Takahiro Kobayashi;Kazuhiro Niimi;Yoshiyuki Kojima;Yasue Kubota;Takahiro Yasui;Keiichi Tozawa;Shoichi Sasaki;and Kenjiro Kohri
• 通讯作者: and Kenjiro Kohri

Efficacy of a selective alpha 1A adrenoceptor antagonist as a medical expulsive therapy against ureteral stones.

选择性α1A肾上腺素受体拮抗剂作为输尿管结石药物排出疗法的功效。

• 发表时间: 2011
• 作者: Yasunori Itoh;Atsushi Okada;Takahiro Yasui;Yasufumi Fujii;Yasuhiko Hirose;Masayuki Usami;Shuzo Hamamoto;Masahito Hirose;Keiji Fujita;Keiichi Tozawa;and Kenjiro Kohri.
• 通讯作者: and Kenjiro Kohri.

Administration of the selective alpha 1A-adrenoceptor antagonist silodosin facilitates expulsion of size 5-10 mm distal ureteral stones, as compared to control

• DOI: 10.1007/s11255-013-0429-8
• 发表时间: 2013-06-01
• 期刊: INTERNATIONAL UROLOGY AND NEPHROLOGY
• 影响因子: 2
• 作者: Itoh, Yasunori;Okada, Atsushi;Kohri, Kenjiro
• 通讯作者: Kohri, Kenjiro

Efficacy of retroperitoneal laparoscopic ureterolithotomy for the treatment of large proximal ureteric stones and its impact on renal function.

腹膜后腹腔镜输尿管碎石术治疗输尿管近端大结石的疗效及其对肾功能的影响。

• DOI: 10.1186/2193-1801-2-600
• 发表时间: 2013
• 期刊: SpringerPlus
• 作者: Yasui T;Okada A;Hamamoto S;Taguchi K;Ando R;Mizuno K;Itoh Y;Tozawa K;Hayashi Y;Kohri K
• 通讯作者: Kohri K