Development of new strategy for treatment of endometriosis with focus on the interaction of NEP and PTEN

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We found the expression of neutral endopeptidase(NEP), CD44(hyaluronan receptor) and PTEN in human endometrial stromal cells and endometriotic stromal cells. We also found that NEP is induced with progesterone. While the interaction of NEP and PTEN did not affect the signaling pathway of PI3K-Akt, NEP suppressed the CD44-dependent cell adhesion due to the inhibition of the interaction between CD44 and Ezrin/Radixin/Moesin(ERM) by NEP. The induction of NEP expression might lead to the development of the novel therapy of endometriosis.