Investigate the new serum markers and create clinical guidelines for the diagnosis of amniotic fluid embolism

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The new serum marker would be identify from the protein specially or exclusively present in amniotic fluid by proteomic analysis. The method for detecting circulating levels of the new marker which is high ratio of amnion/serum level may be a sensitive method for diagnosis of AFE. One hundred and thirty-five patients met the criteria of AFE, which included fatal (n=65) and non-fatal AFE (n=70). Maternal full term gestational weeks, multiparous, non-cesarean sections, Sialyl Tn (STN) levels, IL-8 levels, cardiac arrest, dyspnea and loss of consciousness were the risk factors for death found in this study using by chi-square analysis(p<0.01).In regard to each case, an increase in the proportion of lethal factor will also lead to the increase of mortality. It would be adequate for creating the prognostic score of AFE.