elucidate a role of the meconium in the fatal cause of the amniotic fluid embolism

阐明胎便在羊水栓塞致命原因中的作用

• 批准号: 23592410
• 负责人: OI Hidekazu
• 金额: $ 3.33万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592410/
• 关键词: 羊水塞栓症; 羊水; 胎便; 分娩後異常母体出血; SCC; Sialyl Tn; STN; 分娩時出血量

The case that serum level of STN and CEA which were contained rich in meconium rose to after delivery was considered as the case that a meconium ingredient entered into the maternal circulation. The correlation between the difference in serum level of these tumor markers at the peripartum period and APPH was investigated statistically. And the correlation of each values of STN, CEA, C3, C4, FDP-DD in maternal serum in two groups with turbid amniotic fluid and clear amniotic fluid and APPH was investigated also. The result of making a study for the correlation between the difference of each values in maternal serum at peripartum period and APPH was not proved statistically. But the correlation between turbid amniotic fluid and APPH was observed significantly (P<0.05). The possibilities were suggested that when a large amount of turbid AF entered into maternal circulation, APPH will be occurred. This phenomenon will lead to the poor prognosis in the patients with amniotic fluid embolism.

富含胎便的血清STN和CEA浓度在分娩后上升的情况被认为是胎便成分进入母体循环的情况。统计分析围产期血清肿瘤标志物水平差异与APPH的相关性。并考察两组母血清中STN、CEA、C3、C4、FDP-DD各值与羊水浑浊、羊水清澈的情况与APPH的相关性。对围产期母体血清中各值的差异与APPH之间的相关性进行研究的结果未得到统计学证明。但羊水混浊与APPH有显着相关性(P<0.05)。提示当大量混浊AF进入母体循环时，可能会发生APPH。这种现象会导致羊水栓塞患者的预后不良。

项目成果

致死的因子を含む割合が関連する羊水塞栓症における死亡率

与致死因素相关的羊水栓塞死亡率

• 发表时间: 2011
• 作者: 三浦清徳;東島愛;長谷川ゆり;阿部修平;築山尚史;三浦生子;山崎健太郎;吉田敦;増崎英明;大井豪一
• 通讯作者: 大井豪一

The entry of fetal and amniotic fluid components into the uterine vessel circulation leads to sterile inflammatory processes during parturition.

• DOI: 10.3389/fimmu.2012.00321
• 发表时间: 2012
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Kobayashi H

登録された羊水塞栓症例における症状別解析により本症の発症原因を探る

通过羊水栓塞登记病例的症状特异性分析探讨该病的病因

• 发表时间: 2012
• 作者: Takahashi K;Mimura K;Kanagawa T;Kinugasa-Taniguchi Y;Endo M;Matsuzaki S;Kumasawa K;Hashimoto K;Tomimatsu T;Kimura T.;大井豪一
• 通讯作者: 大井豪一

Analysis of amniotic fluid embolism between 1992-2006 in Japan

日本1992-2006年羊水栓塞情况分析

• 发表时间: 2011
• 作者: 三浦清徳;増崎英明;大井豪一
• 通讯作者: 大井豪一

amniotic fluid emboli updates

羊水栓塞更新

• 发表时间: 2013
• 作者: 神山雅史;臼井規朗;金川武司;谷岳人;鎌田振吉;福澤正洋;木村正;Oi H
• 通讯作者: Oi H