Proteomic prediction of radiotherapy outcome in cervical cancer

本研究的目的是为了获得数据，作为开发新的分子标记物的基础，用于预测宫颈癌患者放疗的结果。受试者从对同步放化疗（CCRT）敏感或耐药的病例中选择。比较敏感和耐药病例治疗前活检标本的综合蛋白表达谱。鉴定了8种仅在敏感病例中表达的蛋白质，而鉴定了18种仅在耐药病例中表达的蛋白质。

The present study was conducted in order to obtain data that serve as a basis for developing novel molecular markers for prediction of the outcome of radiotherapy in patients with cervical cancer. Subjects were selected from cases that were sensitive or resistant to the concurrent chemoradiotherapy (CCRT). Comprehensive protein expression profiles of pre-threapy biopsy specimen were compared between the sensitive and resistant cases. Eight proteins were identified that were expressed only in sensitive cases, while 18 proteins were identified that were expressed only in resistant cases.