Proteomic prediction of radiotherapy outcome in cervical cancer

宫颈癌放疗结果的蛋白质组学预测

• 批准号: 20591956
• 负责人: ASATO Tsuyoshi
• 金额: $ 2.91万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591956/
• 关键词: 子宮頸癌; 放射線治療; 子宮頚癌

The present study was conducted in order to obtain data that serve as a basis for developing novel molecular markers for prediction of the outcome of radiotherapy in patients with cervical cancer. Subjects were selected from cases that were sensitive or resistant to the concurrent chemoradiotherapy (CCRT). Comprehensive protein expression profiles of pre-threapy biopsy specimen were compared between the sensitive and resistant cases. Eight proteins were identified that were expressed only in sensitive cases, while 18 proteins were identified that were expressed only in resistant cases.

这项研究的目的是为了获得数据，作为开发预测宫颈癌患者放射治疗结果的新分子标志物的基础。受试者是从对同期放化疗(CCRT)敏感或耐药的病例中挑选出来的。比较敏感病例和耐药病例治疗前活检标本的蛋白质表达谱。共鉴定出8种仅在敏感病例中表达的蛋白质，18种仅在耐药病例中表达的蛋白质。

项目成果

プロテオミクス解析による有棘細胞癌予後マーカーの探索

使用蛋白质组学分析寻找鳞状细胞癌的预后标志物

• 发表时间: 2009
• 作者: 山城義人;他
• 通讯作者: 他

The proteomic search for prognosis markers of cutaneous squamous cell carcinoma.

皮肤鳞状细胞癌预后标志物的蛋白质组学研究。

• 发表时间: 2009
• 作者: Yoshito Yamashiro(代表発表者);Kimiko Takei;Masato Umikawa;Tsuyoshi Asato;Kiyohito Taira;Hiroshi Uezato;Ken-ichi Kariya
• 通讯作者: Ken-ichi Kariya

Localization of Rap2 in recycling endosome in a palmitoylation-dependent manner.

Rap2 以棕榈酰化依赖性方式定位于再循环核内体中。

• 发表时间: 2008
• 作者: Maitsetseg Bayarjargal(代表発表者);Yukiko Uechi;Shogo Endo;Kimiko Nonaka-Takei;Minoru Oshiro;Masato Umikawa;Tsuyoshi Asato;Yoshito Yamashiro;Tomohiko Taguchi;Ken-ichi Kariya
• 通讯作者: Ken-ichi Kariya

Impact of human papillomavirus genotype on response to treatment and survical in patients receiving radiotherapy for squamous cell carcioma of the cervix.

人乳头瘤病毒基因型对接受宫颈鳞状细胞癌放疗的患者的治疗反应和生存的影响。

• 发表时间: 2010
• 期刊: Exp.Therap.Med. 1
• 作者: Ferdousi;J.;Nagai;Y.;Asato;T.;Hirakawa;M.;Inamine;M.;Kudaka;W.;Kariya;K.;Aoki;Y.
• 通讯作者: Y.

Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma.

角蛋白 8 和 18 的异位共表达可促进转化的角质形成细胞的侵袭，并在皮肤鳞状细胞癌患者中诱导。

• 发表时间: 2010
• 期刊: Biochem Biophys Res Commun
• 作者: Yamashiro;Y.;et al.
• 通讯作者: et al.