Clinical usefulness and application of Taxol-resisitance molecules

紫杉醇抗性分子的临床用途和应用

• 批准号: 20592014
• 负责人: MASUYAMA Keisuke
• 金额: $ 2.91万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592014/
• 关键词: 抗癌剤耐性分子; 癌幹細胞; 制御性T細胞; 頭頸部癌; タキサン系抗癌剤; 免疫療法; TRAG-3; 免疫化学療法

We found that head and neck cancer stem cells appeared to be resistant to the treatment of anti-cancer drugs. We did not find any differences of TRAG-3 mRNA expressions between CD44+ and CD44- cells of head and neck cancer cell lines. In addition, CD44+ cells significantly suppressed T cell proliferation. As for cytokine production, IFN・was reduced, however, IL-10 was increased when co-cultured with CD44+ cells. Thus, immunosuppressive mechanisims other than TRAG-3 expression may have a role for anti-cancer drug resistance.

我们发现头颈癌干细胞似乎对抗癌药物的治疗有抵抗力。我们没有发现头颈癌细胞系CD44+和CD44-细胞之间TRAG-3 mRNA表达存在任何差异。此外，CD44+细胞显着抑制T细胞增殖。至于细胞因子的产生，与CD44+细胞共培养时，IFN·减少，但IL-10增加。因此，TRAG-3表达以外的免疫抑制机制可能在抗癌药物耐药性中发挥作用。

项目成果

サルベージ手術後の縫合不全に対して皮弁再建を試行した下咽頭癌の1症例

下咽癌抢救术后缝合失败尝试皮瓣重建1例

• 发表时间: 2010
• 作者: 近松一朗;他;森山元大,増山敬祐
• 通讯作者: 森山元大,増山敬祐

Expression of VEGF-C in oral squamous cell carcinoma correlates with sentinel lymph node lymphangiogenesis.

口腔鳞状细胞癌中 VEGF-C 的表达与前哨淋巴结淋巴管生成相关。

• 发表时间: 2010
• 作者: 石井裕貴;近松一朗;坂倉浩一;宮田政則,古屋信彦;増山敬祐.
• 通讯作者: 増山敬祐.

Th1/Th2 CD4+ T helper responses against wild-type sequence p53 peptides in HLA-DP5 patients with head and neck cancer

头颈癌 HLA-DP5 患者中 Th1/Th2 CD4 T 辅助细胞对野生型序列 p53 肽的反应

• 发表时间: 2008
• 作者: Chikamatsu K;et al.
• 通讯作者: et al.

Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck.

• DOI: 10.1002/hed.21420
• 发表时间: 2011-02
• 期刊: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
• 影响因子: 2.9
• 作者: Chikamatsu, Kazuaki;Takahashi, Goro;Sakakura, Koichi;Ferrone, Soldano;Masuyama, Keisuke
• 通讯作者: Masuyama, Keisuke

Primary tumor induces sentinel lymph node lymphangiogenesis in oral squamous cell carcinoma

• DOI: 10.1016/j.oraloncology.2010.02.014
• 发表时间: 2010-05-01
• 期刊: ORAL ONCOLOGY
• 影响因子: 4.8
• 作者: Ishii, Hiroki;Chikamatsu, Kazuaki;Masuyama, Keisuke
• 通讯作者: Masuyama, Keisuke