Studies on the pathogenesis and development of pharmacological treatment of retinopathy of prematurity

采用实时荧光定量PCR技术研究了氧诱导视网膜病变小鼠和对照小鼠的基因表达谱。在新生血管形成（NV）发生前2天观察到与炎症相关的基因上调，并持续至NV消失后几天。另一方面，与NV相关的基因，如血管内皮生长因子和血管生成素-2的上调，观察到从NV的发展前一天，直到NV的消失。

Gene expression profiles of oxygen-induced retinopathy and control mice were investigated using real-time PCR. Upregulation of genes associated with inflammation were observed 2 days before the development of neovascularization (NV), and continued until a few days after disappearance of NV. On the other hand, upregulation of genes associated with NV, such as vascular endothelial growth factor and angiopoietin-2, were observed from one day before the development of NV until the disappearance of NV.