The development of cartilage regeneration methods using the human auricular cartilage progenitor cells in craniofacial deformity.

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Human cartilage progenitor cells(hCPCs), which were isolated from auricular perichondrium had not only high proliferative and multipotent capacity that human condrocytes(hCs) did not have, but had same cartilage extracellular matrix capacity as hCs. Furthermore, in vivo hCPCs formed the cartilage with perichondrium as normal auricular cartilage. The hCPCs with hydroxyapatite/chondroitin sulfate composite also formed larger cartilage in vivo.