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Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides

Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides
脂多糖刺激的内皮细胞中细胞因子 mRNA 降解对长期低温的影响
批准号:
20592129
负责人:
SAKURAI Atsushi
金额:
$1.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
This experimental study investigated the production of interleukin (IL)-8 protein and its mRNA expression and stability in endothelial cells stimulated by lipopolysaccharides (LPS) and undergoing long-term hypothermia. Under long-term hypothermia, IL-8 protein production was suppressed, while IL-8 mRNA was stabilized at the point of turn-over and expression increased. The potential of IL-8 production for the inflammatory stimulation in endothelial cells may persist during long-term hypothermia.
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会议论文
長期低温下培養にlipopolysaccharideで刺激した人臍帯血内皮細胞におけるinterleukin-8の蛋白産生とmRNA発現の経時的変化
长期低温培养过程中脂多糖刺激的人脐带血内皮细胞蛋白质产生和白细胞介素8 mRNA表达的时间依赖性变化
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳, Atsushi Sakurai, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳]
通讯作者: 櫻井淳
Lipopolysaccharide刺激下に長期低体培養した人臍帯血内皮細胞でのinterleukin-8の蛋白産生とmRNA発現の経時的変化
脂多糖刺激下长期低效培养的人脐带血内皮细胞蛋白质产生和白细胞介素8 mRNA表达的时间依赖性变化
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳, Atsushi Sakurai, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳]
通讯作者: 櫻井淳
DOI: 10.1089/ther.2012.0010
发表时间: 2012-06-01
期刊: THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
影响因子: 1.2
作者: [Sakurai, Atsushi, Kinoshita, Kosaku, Tanjoh, Katsuhisa]
通讯作者: Tanjoh, Katsuhisa
Changes caused by hypothermia in interleukin-8 mRNA stability in human endothelial cells stimulated by lipopolysaccharide.
低温引起脂多糖刺激的人内皮细胞中白细胞介素 8 mRNA 稳定性的变化。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳]
通讯作者: 櫻井淳
8
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