Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides
Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides
批准号:
20592129
负责人:
SAKURAI Atsushi
金额:
$1.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
This experimental study investigated the production of interleukin (IL)-8 protein and its mRNA expression and stability in endothelial cells stimulated by lipopolysaccharides (LPS) and undergoing long-term hypothermia. Under long-term hypothermia, IL-8 protein production was suppressed, while IL-8 mRNA was stabilized at the point of turn-over and expression increased. The potential of IL-8 production for the inflammatory stimulation in endothelial cells may persist during long-term hypothermia.
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長期低温下培養にlipopolysaccharideで刺激した人臍帯血内皮細胞におけるinterleukin-8の蛋白産生とmRNA発現の経時的変化
长期低温培养过程中脂多糖刺激的人脐带血内皮细胞蛋白质产生和白细胞介素8 mRNA表达的时间依赖性变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳, Atsushi Sakurai, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳]
通讯作者:
櫻井淳
Lipopolysaccharide刺激下に長期低体培養した人臍帯血内皮細胞でのinterleukin-8の蛋白産生とmRNA発現の経時的変化
脂多糖刺激下长期低效培养的人脐带血内皮细胞蛋白质产生和白细胞介素8 mRNA表达的时间依赖性变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳, Atsushi Sakurai, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳, 櫻井淳]
通讯作者:
櫻井淳
DOI:
10.1089/ther.2012.0010
发表时间:
2012-06-01
期刊:
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
影响因子:
1.2
作者:
[Sakurai, Atsushi, Kinoshita, Kosaku, Tanjoh, Katsuhisa]
通讯作者:
Tanjoh, Katsuhisa
Changes caused by hypothermia in interleukin-8 mRNA stability in human endothelial cells stimulated by lipopolysaccharide.
低温引起脂多糖刺激的人内皮细胞中白细胞介素 8 mRNA 稳定性的变化。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳]
通讯作者:
櫻井淳
Lipopolysaccharide刺激下に培養した人臍帯血内皮細胞での低温によるIL-6とIL-8のmRNAの安定性変化の検討
脂多糖刺激下培养的人脐带血内皮细胞低温引起的IL-6和IL-8 mRNA稳定性变化的检测
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh, 櫻井淳, Atsushi Sakurai, 櫻井淳, 櫻井淳, 櫻井淳]
通讯作者:
櫻井淳
共 8 条
Thermal radiation control by metamaterial and application to solar thermophotovoltaic power generation
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批准号:15K17985
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2015
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负责人:SAKURAI Atsushi
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依托单位:
The significances of the oral history on the social problems in postwar Japan
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财政年份:2012
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负责人:SAKURAI Atsushi
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依托单位:
Development of new equipment for intra-arrest brain cooling that uses cooled oxygen in the lungs: volunteer study
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批准号:24592751
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.33万
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财政年份:2012
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负责人:SAKURAI Atsushi
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依托单位:
A study of heat transfer simulation for the development of high-efficiency fluidized bed solar reactor
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批准号:23760844
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
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财政年份:2011
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负责人:SAKURAI Atsushi
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依托单位:
SOCIOLOGICAL RESEARCH ON THE ACTIVITES OF CONVEYING THE PEOPLE's WAR EXPERIENCES AND THE REPRESENTATION OF THEM
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批准号:21530562
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2009
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负责人:SAKURAI Atsushi
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依托单位:
LIFE STORIES OF MEAT AND LEATHER WORKERS AND THE TRANSFORMATION OF A DISCRIMINATED IDENTITY
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批准号:15330095
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.03万
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财政年份:2003
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依托单位:
LIFE-HISTORY RESEARCH ON MASCULINITY OF THE BABY-BOOM GENERATION
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批准号:12610168
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负责人:SAKURAI Atsushi
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依托单位:
海外基金