The pathogenic mechanisms of peripheral nerve disorders associated with severe sepsis -A study of the protective effect of X factor inhibitor-

虽然周围神经紊乱与败血症有关，但其致病机制尚不清楚，治疗方法也不完善。我们的数据表明，在没有电镜变性的情况下，流变酶的增加表明，脓毒症早期周围神经组织可能发生阈值的改变，而不是退行性改变。这提示这些因素可能与周围神经紊乱，如危重性多发性神经病有关。此外，由于达那那肽与抗凝血酶3联合使用可改善临床，我们的数据提示其可能显著影响脓毒症合并严重周围神经病变的医学治疗。

Although peripheral nerve disorders are associated with sepsis, the pathogenic mechanisms involved have yet to be clarified and treatment is not well established. Our data demonstrated that increase of rheobase without electro-microscopic degeneration implied that alteration of threshold, rather than degenerative changes, might develop in peripheral nerve tissue in the early phases of sepsis. This suggests the possibility that these factors are likely to be associated with peripheral nerve disorders such as critical illness polyneuropathy. Furthermore, since the combined effect of danaparoid and antithrombin3 resulted in clinical improvement, our data suggests that it might significantly affect the medical treatment of severe peripheral neuropathy associated with sepsis.