Study on the mechanisms of pathogenesis of critical illness polyneuropathy and protective effect of activated factor X.
危重症多发性神经病发病机制及活化因子X的保护作用研究。
基本信息
- 批准号:23592687
- 负责人:
- 金额:$ 2.66万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2013
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We measured the expression of eight kinds of voltage-dependent sodium channel receptor subtypes (Nav) of the sciatic nerve by the real-time PCR method in sepsis induced critical illness polyneuropathy rat model (L-group) and compared to the control group (C-group). We achieved the results shown the significant reductions of gene expression in three subtypes of Nav and increases in three different kinds of Nav in L-group compared to C-group. These data implied the different types of sodium channel gene expression plays an important role in the mechanisms of pathogenesis of critical illness polyneuropathy as channelopathy.Since the administration of Drug-X and/or Drug-Y did not improve the alteration in Nav gene expression, other actions of Drug-X and Drug-Y might be involved in the improvement of nerve function during sepsis.
采用实时荧光定量PCR方法检测脓毒症重症多发性神经病大鼠模型(L组)坐骨神经8种电压依赖性钠通道受体亚型(Nav)的表达,并与对照组(C组)进行比较。结果显示,与C组相比,L组的三种Nav亚型的基因表达显著降低,而三种不同类型的Nav的基因表达显著升高。这些数据提示不同类型的钠通道基因表达在重症多发性神经病的发病机制中起着重要作用,由于给予Drug-X和/或Drug-Y不能改善Nav基因表达的改变,Drug-X和Drug-Y可能参与了脓毒症时神经功能的改善。
项目成果
期刊论文数量(0)
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HINO Hirofumi其他文献
HINO Hirofumi的其他文献
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{{ truncateString('HINO Hirofumi', 18)}}的其他基金
The pathogenic mechanisms of peripheral nerve disorders associated with severe sepsis -A study of the protective effect of X factor inhibitor-
严重脓毒症相关周围神经障碍的发病机制-X因子抑制剂的保护作用研究-
- 批准号:
20592130 - 财政年份:2008
- 资助金额:
$ 2.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)