Study on the mechanisms of pathogenesis of critical illness polyneuropathy and protective effect of activated factor X.

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We measured the expression of eight kinds of voltage-dependent sodium channel receptor subtypes (Nav) of the sciatic nerve by the real-time PCR method in sepsis induced critical illness polyneuropathy rat model (L-group) and compared to the control group (C-group). We achieved the results shown the significant reductions of gene expression in three subtypes of Nav and increases in three different kinds of Nav in L-group compared to C-group. These data implied the different types of sodium channel gene expression plays an important role in the mechanisms of pathogenesis of critical illness polyneuropathy as channelopathy.Since the administration of Drug-X and/or Drug-Y did not improve the alteration in Nav gene expression, other actions of Drug-X and Drug-Y might be involved in the improvement of nerve function during sepsis.