Research for non-cholinergic toxicity of a sarin-like organophosphate on animal cardiovascular system.

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We administered intravenously a sarin-like organophosphate BIMP into rats and found that high doses of BIMP caused increases both of blood pressure and heart rate. Pretreatment of some blockers showed that these effects of BIMP might not be mediated by cholinergic-neuron, but act directly on blood vessels and hearts of the animals injected BIMP.To examine the direct effect to vessels, we analyzed the effect of BIMP to iNOS expression in rat aortic smooth-muscle cells. The results showed that BIMP modified efficiency of iNOS induction, but these works were required further validation.