Evaluation of the neurological substrates for stress induced oral dysesthesia.

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The central nucleus of amygdala and the locus coeruleus are proved to send direct projections to the mesencephalic trigeminal nucleus. Injections of neuronal tract tracers (biotinylated dextran amine, Fast blue) revealed that limited injections of Fast blue into the mesencephalic trigeminal nucleus resulted in retrogradely labeled cells in the central amygdaloid nucleus. Orthograde labeling of the central amygdaloid nucleus resulted in terminal swellings in the mesencephalic trigeminal nucleus. Electron microscopic observation confirmed these findings. Selective cellular labeling of the locus coeruleus using biotinilated dextran amine revealed that the axons of locus coeruleus neurons were followed directly to the mesencephalic trigeminal nucleus gangion cells. The results suggest that emotion and stress directly modify proprioceptive signals from periodontal ligament and masticatory muscles.