The difference of nature and functional role between tumor-nest versus tumor-stroma infiltrating lymphocytes in oral cancer.

口腔癌中肿瘤巢与肿瘤基质浸润淋巴细胞之间的性质和功能作用的差异。

• 批准号: 20592325
• 负责人: KATOU Fuminori
• 金额: $ 2.33万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592325/
• 关键词: 口腔癌; リンパ球; NK細胞; 樹状細胞; 活性化

We identified the tumor-nest and tumor-stroma infiltrating lymphocytes, and examined their functional role and activation status. In the tumor nest inhibitory CD8+ CTLs were abundant, but in the tumor stroma they were scarce. On the contrary, activated CD8+ CTLs and CD4+ T cells plentifully infiltrated to the tumor stroma.

我们鉴定了肿瘤巢细胞和肿瘤基质浸润淋巴细胞，并检测了它们的功能作用和激活状态。在瘤巢中抑制性CD8+ ctl丰富，而在瘤间质中则较少。相反，活化的CD8+ ctl和CD4+ T细胞大量浸润到肿瘤基质。

项目成果

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• DOI: 10.1016/j.tripleo.2009.12.015
• 发表时间: 2010-05-01
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• DOI: 10.4049/jimmunol.0904126
• 发表时间: 2010-12-01
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