Oral cancer therapy by differential temperature control using nano-particle

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The cell proliferation was significantly suppressed by 44℃ treatment compared with 37℃ and 42℃. The cell death ratios at 12 hours after heat treatment were 5.0% at 42℃ and 17.4% at 44℃. Computational gene network analysis demonstrated the threesignificant gene networks. As for heat treatment at 42℃, the significant gene network contained many HSPs such as HSP70 and DNAJB1. As for at 44℃, the significant gene networks whose core contained CDK6 and JUN were associated with cell cycle and cell death, respectively. These findings will provide novel insight into the biomolecular mechanisms of hyperthermia in therapeutic application for oral cancer therapy.